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Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila

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  • Shuo Yang

    (Washington University School of Medicine)

  • Jennifer McAdow

    (Washington University School of Medicine)

  • Yingqiu Du

    (Washington University School of Medicine)

  • Jennifer Trigg

    (Washington University School of Medicine)

  • Paul H. Taghert

    (Washington University School of Medicine)

  • Aaron N. Johnson

    (Washington University School of Medicine)

Abstract

Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of developmental biology, but the mechanisms controlling mitosis and differentiation are considered to be fundamentally distinct. Here we show the mitotic kinase Polo, which regulates all steps of mitosis in Drosophila, also directs cellular morphogenesis after cell cycle exit. In mitotic cells, the Aurora kinases activate Polo to control a cytoskeletal regulatory module that directs cytokinesis. We show that in the post-mitotic mesoderm, the control of Polo activity transitions from the Aurora kinases to the uncharacterized kinase Back Seat Driver (Bsd), where Bsd and Polo cooperate to regulate muscle morphogenesis. Polo and its effectors therefore direct mitosis and cellular morphogenesis, but the transition from growth to morphogenesis is determined by the spatiotemporal expression of upstream activating kinases.

Suggested Citation

  • Shuo Yang & Jennifer McAdow & Yingqiu Du & Jennifer Trigg & Paul H. Taghert & Aaron N. Johnson, 2022. "Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28322-8
    DOI: 10.1038/s41467-022-28322-8
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    References listed on IDEAS

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    1. Cory M. Johannessen & Jesse S. Boehm & So Young Kim & Sapana R. Thomas & Leslie Wardwell & Laura A. Johnson & Caroline M. Emery & Nicolas Stransky & Alexandria P. Cogdill & Jordi Barretina & Giordano , 2010. "COT drives resistance to RAF inhibition through MAP kinase pathway reactivation," Nature, Nature, vol. 468(7326), pages 968-972, December.
    2. David Kachaner & Damien Garrido & Haytham Mehsen & Karine Normandin & Hugo Lavoie & Vincent Archambault, 2017. "Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
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