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Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change

Author

Listed:
  • Rachel A. Steward

    (Stockholm University)

  • Maaike A. de Jong

    (Netherlands eScience Centre)

  • Vicencio Oostra

    (University of Liverpool)

  • Christopher W. Wheat

    (Stockholm University)

Abstract

Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular mechanisms contribute to plasticity or how these mechanisms impact how plasticity evolves. Here, we use transcriptomic and genomic data from the butterfly Bicyclus anynana, a model system for seasonal plasticity, to compare the extent of differential expression and splicing and test how these axes of transcriptional plasticity differ in their potential for evolutionary change. Between seasonal morphs, we find that differential splicing affects a smaller but functionally unique set of genes compared to differential expression. Further, we find strong support for the novel hypothesis that spliced genes are more susceptible than differentially expressed genes to erosion of genetic variation due to selection on seasonal plasticity. Our results suggest that splicing plasticity is especially likely to experience genetic constraints that could affect the potential of wild populations to respond to rapidly changing environments.

Suggested Citation

  • Rachel A. Steward & Maaike A. de Jong & Vicencio Oostra & Christopher W. Wheat, 2022. "Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28306-8
    DOI: 10.1038/s41467-022-28306-8
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    References listed on IDEAS

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    2. Vicencio Oostra & Marjo Saastamoinen & Bas J. Zwaan & Christopher W. Wheat, 2018. "Strong phenotypic plasticity limits potential for evolutionary responses to climate change," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    3. Syed Shamsh Tabrez & Ravi Datta Sharma & Vaibhav Jain & Atif Ahmed Siddiqui & Arnab Mukhopadhyay, 2017. "Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
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