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Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

Author

Listed:
  • Valeria Garcia-Flores

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Roberto Romero

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, University of Michigan
    Department of Epidemiology and Biostatistics, Michigan State University
    Center for Molecular Medicine and Genetics, Wayne State University)

  • Yi Xu

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Kevin R. Theis

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine)

  • Marcia Arenas-Hernandez

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Derek Miller

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Azam Peyvandipour

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    Center for Molecular Medicine and Genetics, Wayne State University)

  • Gaurav Bhatti

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Jose Galaz

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Meyer Gershater

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Dustyn Levenson

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Errile Pusod

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Li Tao

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • David Kracht

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Violetta Florova

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Yaozhu Leng

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Kenichiro Motomura

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Robert Para

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Megan Faucett

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine)

  • Chaur-Dong Hsu

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    Department of Physiology, Wayne State University School of Medicine)

  • Gary Zhang

    (Center for Molecular Medicine and Genetics, Wayne State University)

  • Adi L. Tarca

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    Department of Computer Science, Wayne State University College of Engineering)

  • Roger Pique-Regi

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    Center for Molecular Medicine and Genetics, Wayne State University)

  • Nardhy Gomez-Lopez

    (Perinatology Research Branch, Division of Obstetrics and Maternal–Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services (NICHD/NIH/DHHS)
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine
    Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine)

Abstract

Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells. SARS-CoV-2 infection during pregnancy is also associated with humoral and cellular immune responses in the maternal blood, as well as with a mild cytokine response in the neonatal circulation (i.e., umbilical cord blood), without compromising the T-cell repertoire or initiating IgM responses. Importantly, SARS-CoV-2 is not detected in the placental tissues, nor is the sterility of the placenta compromised by maternal viral infection. This study provides insight into the maternal-fetal immune responses triggered by SARS-CoV-2 and emphasizes the rarity of placental infection.

Suggested Citation

  • Valeria Garcia-Flores & Roberto Romero & Yi Xu & Kevin R. Theis & Marcia Arenas-Hernandez & Derek Miller & Azam Peyvandipour & Gaurav Bhatti & Jose Galaz & Meyer Gershater & Dustyn Levenson & Errile P, 2022. "Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27745-z
    DOI: 10.1038/s41467-021-27745-z
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    Cited by:

    1. Yin Ping Wong & Geok Chin Tan & Siti Zarqah Omar & Muaatamarulain Mustangin & Yogesh Singh & Madhuri S. Salker & Nor Haslinda Abd Aziz & Mohamad Nasir Shafiee, 2022. "SARS-CoV-2 Infection in Pregnancy: Placental Histomorphological Patterns, Disease Severity and Perinatal Outcomes," IJERPH, MDPI, vol. 19(15), pages 1-15, August.

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