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Association between serum retinol and overall and cause-specific mortality in a 30-year prospective cohort study

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  • Jiaqi Huang

    (The Second Xiangya Hospital of Central South University
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services)

  • Stephanie J. Weinstein

    (Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services)

  • Kai Yu

    (Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services)

  • Satu Männistö

    (Department of Public Health Solutions, Finnish Institute for Health and Welfare)

  • Demetrius Albanes

    (Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services)

Abstract

How retinol as a clinical indicator of vitamin A status is related to long-term mortality is unknown. Here we report the results of a prospective analysis examining associations between serum retinol and risk of overall and cause-specific mortality. During a 30-year cohort follow-up, 23,797 deaths were identified among 29,104 men. Participants with higher serum retinol experienced significantly lower overall, CVD, heart disease, and respiratory disease mortality compared to men with the lowest retinol concentrations, reflecting 17–32% lower mortality risk (Ptrend

Suggested Citation

  • Jiaqi Huang & Stephanie J. Weinstein & Kai Yu & Satu Männistö & Demetrius Albanes, 2021. "Association between serum retinol and overall and cause-specific mortality in a 30-year prospective cohort study," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26639-4
    DOI: 10.1038/s41467-021-26639-4
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