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SARS-CoV-2 vaccine breakthrough infections with the alpha variant are asymptomatic or mildly symptomatic among health care workers

Author

Listed:
  • Francesca Rovida

    (Fondazione IRCCS Policlinico San Matteo
    University of Pavia)

  • Irene Cassaniti

    (Fondazione IRCCS Policlinico San Matteo)

  • Stefania Paolucci

    (Fondazione IRCCS Policlinico San Matteo)

  • Elena Percivalle

    (Fondazione IRCCS Policlinico San Matteo)

  • Antonella Sarasini

    (Fondazione IRCCS Policlinico San Matteo)

  • Antonio Piralla

    (Fondazione IRCCS Policlinico San Matteo)

  • Federica Giardina

    (Fondazione IRCCS Policlinico San Matteo)

  • Josè Camilla Sammartino

    (Fondazione IRCCS Policlinico San Matteo)

  • Alessandro Ferrari

    (Fondazione IRCCS Policlinico San Matteo)

  • Federica Bergami

    (Fondazione IRCCS Policlinico San Matteo)

  • Alba Muzzi

    (Fondazione IRCCS Policlinico San Matteo)

  • Viola Novelli

    (Fondazione IRCCS Policlinico San Matteo)

  • Alessandro Meloni

    (Fondazione IRCCS Policlinico San Matteo
    University of Pavia)

  • Sara Cutti

    (Fondazione IRCCS Policlinico San Matteo)

  • Anna Maria Grugnetti

    (Fondazione IRCCS Policlinico San Matteo)

  • Giuseppina Grugnetti

    (Fondazione IRCCS Policlinico San Matteo)

  • Claudia Rona

    (Fondazione IRCCS Policlinico San Matteo)

  • Marinella Daglio

    (Fondazione IRCCS Policlinico San Matteo)

  • Carlo Marena

    (Fondazione IRCCS Policlinico San Matteo)

  • Antonio Triarico

    (Fondazione IRCCS Policlinico San Matteo)

  • Daniele Lilleri

    (Fondazione IRCCS Policlinico San Matteo)

  • Fausto Baldanti

    (Fondazione IRCCS Policlinico San Matteo
    University of Pavia)

Abstract

Vaccine breakthrough SARS-CoV-2 infection has been monitored in 3720 healthcare workers receiving 2 doses of BNT162b2. SARS-CoV-2 infection is detected in 33 subjects, with a 100-day cumulative incidence of 0.93%. Vaccine protection against acquisition of SARS-CoV-2 infection is 83% (95%CI: 58–93%) in the overall population and 93% (95%CI: 69-99%) in SARS-CoV-2-experienced subjects, when compared with a non-vaccinated control group from the same Institution, in which SARS-CoV-2 infection occurs in 20/346 subjects (100-day cumulative incidence: 5.78%). The infection is symptomatic in 16 (48%) vaccinated subjects vs 17 (85%) controls (p = 0.01). All analyzed patients, in whom the amount of viral RNA was sufficient for genome sequencing, results infected by the alpha variant. Antibody and T-cell responses are not reduced in subjects with breakthrough infection. Evidence of virus transmission, determined by contact tracing, is observed in two (6.1%) cases. This real-world data support the protective effect of BNT162b2 vaccine. A triple antigenic exposure, such as two-dose vaccine schedule in experienced subjects, may confer a higher protection.

Suggested Citation

  • Francesca Rovida & Irene Cassaniti & Stefania Paolucci & Elena Percivalle & Antonella Sarasini & Antonio Piralla & Federica Giardina & Josè Camilla Sammartino & Alessandro Ferrari & Federica Bergami &, 2021. "SARS-CoV-2 vaccine breakthrough infections with the alpha variant are asymptomatic or mildly symptomatic among health care workers," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26154-6
    DOI: 10.1038/s41467-021-26154-6
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    Cited by:

    1. Jernej Pušnik & Werner O. Monzon-Posadas & Jasmin Zorn & Kathrin Peters & Maximilian Baum & Hannah Proksch & Celina Beta Schlüter & Galit Alter & Tanja Menting & Hendrik Streeck, 2023. "SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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