IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25990-w.html
   My bibliography  Save this article

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

Author

Listed:
  • Guohao Wang

    (University of Macau
    University of Macau)

  • Lisi Xie

    (University of Macau
    University of Macau)

  • Bei Li

    (University of Macau
    University of Macau)

  • Wei Sang

    (University of Macau
    University of Macau)

  • Jie Yan

    (University of Macau
    University of Macau)

  • Jie Li

    (University of Macau
    University of Macau)

  • Hao Tian

    (University of Macau
    University of Macau)

  • Wenxi Li

    (University of Macau
    University of Macau)

  • Zhan Zhang

    (University of Macau
    University of Macau)

  • Ye Tian

    (University of Macau
    University of Macau)

  • Yunlu Dai

    (University of Macau
    University of Macau
    University of Macau)

Abstract

In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this scenario, suppressing the secretion of tumor-derived exosomes may aid therapy. Here, we develop an assembly of exosome inhibitor (GW4869) and ferroptosis inducer (Fe3+) via amphiphilic hyaluronic acid. Cooperation between the two active components in the constructed nanounit induces an anti-tumor immunoresponse to B16F10 melanoma cells and stimulates cytotoxic T lymphocytes and immunological memory. The nanounit enhances the response to PD-L1 checkpoint blockade and may represent a therapeutic strategy for enhancing the response to this therapy.

Suggested Citation

  • Guohao Wang & Lisi Xie & Bei Li & Wei Sang & Jie Yan & Jie Li & Hao Tian & Wenxi Li & Zhan Zhang & Ye Tian & Yunlu Dai, 2021. "A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25990-w
    DOI: 10.1038/s41467-021-25990-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25990-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25990-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25990-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.