IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25857-0.html
   My bibliography  Save this article

A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

Author

Listed:
  • Fumihiro Kodama

    (Sapporo City General Hospital
    Nagaoka Red Cross Hospital)

  • Hiroki Yamaguchi

    (Hokkaido Institute of Public Health)

  • Eunsil Park

    (National Institute of Infectious Diseases)

  • Kango Tatemoto

    (National Institute of Infectious Diseases)

  • Mariko Sashika

    (Hokkaido University)

  • Ryo Nakao

    (Hokkaido University)

  • Yurino Terauchi

    (Hokkaido University)

  • Keita Mizuma

    (Hokkaido University)

  • Yasuko Orba

    (Hokkaido University
    Hokkaido University)

  • Hiroaki Kariwa

    (Hokkaido University)

  • Katsuro Hagiwara

    (Rakuno Gakuen University)

  • Katsunori Okazaki

    (Health Sciences University of Hokkaido)

  • Akiko Goto

    (Hokkaido Institute of Public Health)

  • Rika Komagome

    (Hokkaido Institute of Public Health)

  • Masahiro Miyoshi

    (Hokkaido Institute of Public Health)

  • Takuya Ito

    (Hokkaido Institute of Public Health)

  • Kimiaki Yamano

    (Hokkaido Institute of Public Health)

  • Kentaro Yoshii

    (Nagasaki University)

  • Chiaki Funaki

    (Hokkaido University)

  • Mariko Ishizuka

    (Hokkaido University)

  • Asako Shigeno

    (Hokkaido University)

  • Yukari Itakura

    (Hokkaido University)

  • Lesley Bell-Sakyi

    (University of Liverpool)

  • Shunji Edagawa

    (Sapporo City General Hospital)

  • Atsushi Nagasaka

    (Sapporo City General Hospital)

  • Yoshihiro Sakoda

    (Hokkaido University)

  • Hirofumi Sawa

    (Hokkaido University
    Hokkaido University
    Hokkaido University
    Global Virus Network)

  • Ken Maeda

    (National Institute of Infectious Diseases)

  • Masayuki Saijo

    (National Institute of Infectious Diseases)

  • Keita Matsuno

    (Hokkaido University
    Hokkaido University
    Hokkaido University)

Abstract

The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.

Suggested Citation

  • Fumihiro Kodama & Hiroki Yamaguchi & Eunsil Park & Kango Tatemoto & Mariko Sashika & Ryo Nakao & Yurino Terauchi & Keita Mizuma & Yasuko Orba & Hiroaki Kariwa & Katsuro Hagiwara & Katsunori Okazaki & , 2021. "A novel nairovirus associated with acute febrile illness in Hokkaido, Japan," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25857-0
    DOI: 10.1038/s41467-021-25857-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25857-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25857-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25857-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.