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A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome

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Listed:
  • Yafen Wang

    (Wuhan University)

  • Shaoqing Han

    (Wuhan University)

  • Ruoxi Ran

    (Zhongnan Hospital of Wuhan University)

  • Anling Li

    (Zhongnan Hospital of Wuhan University)

  • Huanyu Liu

    (Zhongnan Hospital of Wuhan University)

  • Mingjun Liu

    (Zhongnan Hospital of Wuhan University)

  • Yongwei Duan

    (Zhongnan Hospital of Wuhan University)

  • Xiong Zhang

    (Wuhan University)

  • Zhigang Zhao

    (Zhongnan Hospital of Wuhan University, Wuhan University)

  • Shihui Song

    (Zhongnan Hospital of Wuhan University, Wuhan University)

  • Xiaocheng Weng

    (Wuhan University)

  • Song-Mei Liu

    (Zhongnan Hospital of Wuhan University)

  • Xiang Zhou

    (Wuhan University)

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease caused by a new type of SFTS virus (SFTSV). Here, a longitudinal sampling study is conducted to explore the differences in transcript levels after SFTSV infection, and to characterize the transcriptomic and epigenetic profiles of hospitalized patients. The results reveal significant changes in the mRNA expression of certain genes from onset to recovery. Moreover, m6A-seq reveals that certain genes related with immune regulation may be regulated by m6A. Besides the routine tests such as platelet counts, serum ALT and AST levels testing, distinct changes in myocardial enzymes, coagulation function, and inflammation are well correlated with the clinical data and sequencing data, suggesting that clinical practitioners should monitor the above indicators to track disease progression and guide personalized treatment. In this study, the transcript changes and RNA modification may lend a fresh perspective to our understanding of the SFTSV and play a significant role in the discovery of drugs for effective treatment of this disease.

Suggested Citation

  • Yafen Wang & Shaoqing Han & Ruoxi Ran & Anling Li & Huanyu Liu & Mingjun Liu & Yongwei Duan & Xiong Zhang & Zhigang Zhao & Shihui Song & Xiaocheng Weng & Song-Mei Liu & Xiang Zhou, 2021. "A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25804-z
    DOI: 10.1038/s41467-021-25804-z
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