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Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen

Author

Listed:
  • Sanam Soomro

    (University of Houston)

  • Suresh Venkateswaran

    (Emory University School of Medicine and Children Health Care of Atlanta)

  • Kamala Vanarsa

    (University of Houston)

  • Marwa Kharboutli

    (University of Houston)

  • Malavika Nidhi

    (University of Houston)

  • Ramya Susarla

    (University of Houston)

  • Ting Zhang

    (University of Houston)

  • Prashanth Sasidharan

    (University of Houston)

  • Kyung Hyun Lee

    (Center for Clinical Research and Evidence-based Medicine, McGovern Medical School, UT Health Science Center at Houston)

  • Joel Rosh

    (Division of Gastroenterology, Hepatology, and Nutrition, Goryeb Children’s Hospital, Atlantic Health)

  • James Markowitz

    (Division of Gastroenterology, Hepatology, and Nutrition, Cohen Children’s Medical Center Of New York)

  • Claudia Pedroza

    (Center for Clinical Research and Evidence-based Medicine, McGovern Medical School, UT Health Science Center at Houston)

  • Lee A. Denson

    (Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine)

  • Jeffrey Hyams

    (Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’s Medical Center)

  • Subra Kugathasan

    (Emory University School of Medicine and Children Health Care of Atlanta
    Emory University School of Medicine)

  • Chandra Mohan

    (University of Houston)

Abstract

In the search for improved stool biomarkers for inflammatory bowel disease (IBD), an aptamer-based screen of 1129 stool proteins was conducted using stool samples from an IBD cohort. Here we report that of the 20 proteins subsequently validated by ELISA, stool Ferritin, Fibrinogen, Haptoglobin, Hemoglobin, Lipocalin-2, MMP-12, MMP-9, Myeloperoxidase, PGRP-S, Properdin, Resistin, Serpin A4, and TIMP-1 are significantly elevated in both ulcerative colitis (UC) and Crohn’s disease (CD) compared to controls. When tested in a longitudinal cohort of 50 UC patients at 4 time-points, fecal Fibrinogen, MMP-8, PGRP-S, and TIMP-2 show the strongest positive correlation with concurrent PUCAI and PGA scores and are superior to fecal calprotectin. Unlike fecal calprotectin, baseline stool Fibrinogen, MMP-12, PGRP-S, TIMP-1, and TIMP-2 can predict clinical remission at Week-4. Here we show that stool proteins identified using the comprehensive aptamer-based screen are superior to fecal calprotectin alone in disease monitoring and prediction in IBD.

Suggested Citation

  • Sanam Soomro & Suresh Venkateswaran & Kamala Vanarsa & Marwa Kharboutli & Malavika Nidhi & Ramya Susarla & Ting Zhang & Prashanth Sasidharan & Kyung Hyun Lee & Joel Rosh & James Markowitz & Claudia Pe, 2021. "Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24235-0
    DOI: 10.1038/s41467-021-24235-0
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