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The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

Author

Listed:
  • Liu Teng

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Yu Chen Feng

    (The University of Newcastle)

  • Su Tang Guo

    (Shanxi Cancer Hospital and Institute)

  • Pei Lin Wang

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Teng Fei Qi

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Yi Meng Yue

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Shi Xing Wang

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Sheng Nan Zhang

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Cai Xia Tang

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Ting La

    (The University of Newcastle)

  • Yuan Yuan Zhang

    (The University of Newcastle)

  • Xiao Hong Zhao

    (The University of Newcastle)

  • Jin Nan Gao

    (Shanxi Bethune Hospital)

  • Li Yuan Wei

    (Shanxi Bethune Hospital)

  • Didi Zhang

    (John Hunter Hospital, Hunter New England Health)

  • Jenny Y. Wang

    (University of New South Wales)

  • Yujie Shi

    (Zhengzhou University People’s Hospital)

  • Xiao Ying Liu

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Jin Ming Li

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University)

  • Huixia Cao

    (Zhengzhou University People’s Hospital)

  • Tao Liu

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University
    University of New South Wales)

  • Rick F. Thorne

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University
    The University of Newcastle)

  • Lei Jin

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University
    The University of Newcastle)

  • Feng-Min Shao

    (Zhengzhou University People’s Hospital)

  • Xu Dong Zhang

    (Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University
    The University of Newcastle)

Abstract

Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characterise a non-protein product of the 3q region, the long noncoding RNA (lncRNA) PLANE, which is upregulated in diverse cancer types through copy number gain as well as E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with the nuclear receptor co-repressor 2 (NCOR2) pre-mRNA at intron 45, binds to heterogeneous ribonucleoprotein M (hnRNPM) and facilitates the association of hnRNPM with the intron, thus leading to repression of the alternative splicing (AS) event generating NCOR2-202, a major protein-coding NCOR2 AS variant. This is, at least in part, responsible for PLANE-mediated promotion of cancer cell proliferation and tumorigenicity. These results uncover the function and regulation of PLANE and suggest that PLANE may constitute a therapeutic target in the pan-cancer context.

Suggested Citation

  • Liu Teng & Yu Chen Feng & Su Tang Guo & Pei Lin Wang & Teng Fei Qi & Yi Meng Yue & Shi Xing Wang & Sheng Nan Zhang & Cai Xia Tang & Ting La & Yuan Yuan Zhang & Xiao Hong Zhao & Jin Nan Gao & Li Yuan W, 2021. "The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24099-4
    DOI: 10.1038/s41467-021-24099-4
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