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Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

Author

Listed:
  • Ifedayo M. O. Adetifa

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene and Tropical Medicine, Keppel Street)

  • Sophie Uyoga

    (KEMRI-Wellcome Trust Research Programme)

  • John N. Gitonga

    (KEMRI-Wellcome Trust Research Programme)

  • Daisy Mugo

    (KEMRI-Wellcome Trust Research Programme)

  • Mark Otiende

    (KEMRI-Wellcome Trust Research Programme)

  • James Nyagwange

    (KEMRI-Wellcome Trust Research Programme)

  • Henry K. Karanja

    (KEMRI-Wellcome Trust Research Programme)

  • James Tuju

    (KEMRI-Wellcome Trust Research Programme)

  • Perpetual Wanjiku

    (KEMRI-Wellcome Trust Research Programme)

  • Rashid Aman

    (Ministry of Health, Government of Kenya)

  • Mercy Mwangangi

    (Ministry of Health, Government of Kenya)

  • Patrick Amoth

    (Ministry of Health, Government of Kenya)

  • Kadondi Kasera

    (Ministry of Health, Government of Kenya)

  • Wangari Ng’ang’a

    (Presidential Policy & Strategy Unit, The Presidency, Government of Kenya)

  • Charles Rombo

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Christine Yegon

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Khamisi Kithi

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Elizabeth Odhiambo

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Thomas Rotich

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Irene Orgut

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Sammy Kihara

    (Kenya National Blood Transfusion Services, Ministry of Health)

  • Christian Bottomley

    (London School of Hygiene and Tropical Medicine, Keppel Street)

  • Eunice W. Kagucia

    (KEMRI-Wellcome Trust Research Programme)

  • Katherine E. Gallagher

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene and Tropical Medicine, Keppel Street)

  • Anthony Etyang

    (KEMRI-Wellcome Trust Research Programme)

  • Shirine Voller

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene and Tropical Medicine, Keppel Street)

  • Teresa Lambe

    (Nuffield Department of Medicine, Oxford University)

  • Daniel Wright

    (Nuffield Department of Medicine, Oxford University)

  • Edwine Barasa

    (KEMRI-Wellcome Trust Research Programme)

  • Benjamin Tsofa

    (KEMRI-Wellcome Trust Research Programme)

  • Philip Bejon

    (KEMRI-Wellcome Trust Research Programme
    Nuffield Department of Medicine, Oxford University)

  • Lynette I. Ochola-Oyier

    (KEMRI-Wellcome Trust Research Programme)

  • Ambrose Agweyu

    (KEMRI-Wellcome Trust Research Programme)

  • J. Anthony G. Scott

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene and Tropical Medicine, Keppel Street
    Nuffield Department of Medicine, Oxford University)

  • George M. Warimwe

    (KEMRI-Wellcome Trust Research Programme
    Nuffield Department of Medicine, Oxford University)

Abstract

Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.

Suggested Citation

  • Ifedayo M. O. Adetifa & Sophie Uyoga & John N. Gitonga & Daisy Mugo & Mark Otiende & James Nyagwange & Henry K. Karanja & James Tuju & Perpetual Wanjiku & Rashid Aman & Mercy Mwangangi & Patrick Amoth, 2021. "Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya," Nature Communications, Nature, vol. 12(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24062-3
    DOI: 10.1038/s41467-021-24062-3
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    Cited by:

    1. Helmut A. Nyawale & Nyambura Moremi & Mohamed Mohamed & Johnson Njwalila & Vitus Silago & Manuel Krone & Eveline T. Konje & Mariam M. Mirambo & Stephen E. Mshana, 2022. "High Seroprevalence of SARS-CoV-2 in Mwanza, Northwestern Tanzania: A Population-Based Survey," IJERPH, MDPI, vol. 19(18), pages 1-13, September.

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