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Ni-catalyzed hydroaminoalkylation of alkynes with amines

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  • Wei-Wei Yao

    (Nankai University)

  • Ran Li

    (Nankai University)

  • Hao Chen

    (Nankai University)

  • Ming-Kai Chen

    (Nankai University)

  • Yu-Xin Luan

    (Nankai University)

  • Yi Wang

    (Peking University)

  • Zhi-Xiang Yu

    (Peking University)

  • Mengchun Ye

    (Nankai University)

Abstract

Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy3) effectively promote the reaction.

Suggested Citation

  • Wei-Wei Yao & Ran Li & Hao Chen & Ming-Kai Chen & Yu-Xin Luan & Yi Wang & Zhi-Xiang Yu & Mengchun Ye, 2021. "Ni-catalyzed hydroaminoalkylation of alkynes with amines," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24032-9
    DOI: 10.1038/s41467-021-24032-9
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