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OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection

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  • Jie Lu

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Ping Li

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Ke Ma

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Yang Li

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Hui Yuan

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Junming Zhu

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Weixun Duan

    (Xi Jing Hospital of Fourth Military Medical University)

  • Jingsong Ou

    (First Affiliated Hospital of Sun yat-sen university)

  • Yonghong Huang

    (First hospital affiliated to Dalian medical university)

  • Long Wu

    (Union Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology)

  • Xueliang Pan

    (Center for Biostatistics, the Ohio State University)

  • Hui Zhang

    (Feinberg School of Medicine, Northwestern University)

  • Jie Du

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

  • Yulin Li

    (Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases)

Abstract

Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated with post-discharge survival, and there is a paucity of prognostic markers associated with TA-AAD. Here, we identify nine candidate proteins specific for patietns with TA-AAD in a cross-sectional dataset by unbiased protein screening and in-depth bioinformatic analyses. In addition, we explore their association with short-term and long-term mortality in a derivation cohort of patients with TA-AAD, including an internal (n = 300) and external (n = 236) dataset. An elevated osteoprotegerin (OPG)/tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) ratio was the strongest predictor of overall, 30-day, post-30-day mortality in both datasets and was confirmed to be a strong predictor of mortality in an independent validation cohort (n = 400). Based on OPG/TRAIL ratio-guided risk stratification, patients at high risk (>33) had a higher 1-year mortality (55.6% vs. 4.3%; 68.2% vs. 2.6%) than patients at low risk (

Suggested Citation

  • Jie Lu & Ping Li & Ke Ma & Yang Li & Hui Yuan & Junming Zhu & Weixun Duan & Jingsong Ou & Yonghong Huang & Long Wu & Xueliang Pan & Hui Zhang & Jie Du & Yulin Li, 2021. "OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23787-5
    DOI: 10.1038/s41467-021-23787-5
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