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Curvature in the reproductive tract alters sperm–surface interactions

Author

Listed:
  • Mohammad Reza Raveshi

    (Monash University)

  • Melati S. Abdul Halim

    (Monash University)

  • Sagar N. Agnihotri

    (Monash University
    IITB-Monash Research Academy, IIT Bombay)

  • Moira K. O’Bryan

    (Monash University
    University of Melbourne)

  • Adrian Neild

    (Monash University)

  • Reza Nosrati

    (Monash University)

Abstract

The fallopian tube is lined with a highly complex folded epithelium surrounding a lumen that progressively narrows. To study the influence of this labyrinthine complexity on sperm behavior, we use droplet microfluidics to create soft curved interfaces over a range of curvatures corresponding to the in vivo environment. We reveal a dynamic response mechanism in sperm, switching from a progressive surface-aligned motility mode at low curvatures (larger droplets), to an aggressive surface-attacking mode at high curvatures (smaller droplets of

Suggested Citation

  • Mohammad Reza Raveshi & Melati S. Abdul Halim & Sagar N. Agnihotri & Moira K. O’Bryan & Adrian Neild & Reza Nosrati, 2021. "Curvature in the reproductive tract alters sperm–surface interactions," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23773-x
    DOI: 10.1038/s41467-021-23773-x
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