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DNA origami single crystals with Wulff shapes

Author

Listed:
  • Yong Wang

    (Nanjing University
    Nanjing University)

  • Lizhi Dai

    (Nanjing University
    Nanjing University)

  • Zhiyuan Ding

    (Nanjing University)

  • Min Ji

    (Nanjing University
    Nanjing University)

  • Jiliang Liu

    (National Light Source II, Brookhaven National Laboratory)

  • Hang Xing

    (Hunan University)

  • Xiaoguo Liu

    (Shanghai Jiao Tong University)

  • Yonggang Ke

    (Georgia Institute of Technology and Emory University
    Emory University)

  • Chunhai Fan

    (Shanghai Jiao Tong University)

  • Peng Wang

    (Nanjing University)

  • Ye Tian

    (Nanjing University
    Nanjing University)

Abstract

DNA origami technology has proven to be an excellent tool for precisely manipulating molecules and colloidal elements in a three-dimensional manner. However, fabrication of single crystals with well-defined facets from highly programmable, complex DNA origami units is a great challenge. Here, we report the successful fabrication of DNA origami single crystals with Wulff shapes and high yield. By regulating the symmetries and binding modes of the DNA origami building blocks, the crystalline shapes can be designed and well-controlled. The single crystals are then used to induce precise growth of an ultrathin layer of silica on the edges, resulting in mechanically reinforced silica-DNA hybrid structures that preserve the details of the single crystals without distortion. The silica-infused microcrystals can be directly observed in the dry state, which allows meticulous analysis of the crystal facets and tomographic 3D reconstruction of the single crystals by high-resolution electron microscopy.

Suggested Citation

  • Yong Wang & Lizhi Dai & Zhiyuan Ding & Min Ji & Jiliang Liu & Hang Xing & Xiaoguo Liu & Yonggang Ke & Chunhai Fan & Peng Wang & Ye Tian, 2021. "DNA origami single crystals with Wulff shapes," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23332-4
    DOI: 10.1038/s41467-021-23332-4
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    Cited by:

    1. Martina F. Ober & Anna Baptist & Lea Wassermann & Amelie Heuer-Jungemann & Bert Nickel, 2022. "In situ small-angle X-ray scattering reveals strong condensation of DNA origami during silicification," Nature Communications, Nature, vol. 13(1), pages 1-7, December.

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