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Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Author

Listed:
  • Thi H. O. Nguyen

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Marios Koutsakos

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Carolien E. Sandt

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
    University of Amsterdam)

  • Jeremy Chase Crawford

    (St Jude Children’s Research Hospital)

  • Liyen Loh

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Sneha Sant

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Ludivine Grzelak

    (École Normale Supérieure Paris-Saclay, Université Paris-Saclay Cachan)

  • Emma K. Allen

    (St Jude Children’s Research Hospital)

  • Tim Brahm

    (St Jude Children’s Research Hospital)

  • E. Bridie Clemens

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Maria Auladell

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Luca Hensen

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Zhongfang Wang

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Simone Nüssing

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Xiaoxiao Jia

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Patrick Günther

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Adam K. Wheatley

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Stephen J. Kent

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
    Monash University
    University of Melbourne)

  • Malet Aban

    (at The Peter Doherty Institute for Infection and Immunity)

  • Yi-Mo Deng

    (at The Peter Doherty Institute for Infection and Immunity)

  • Karen L. Laurie

    (at The Peter Doherty Institute for Infection and Immunity)

  • Aeron C. Hurt

    (at The Peter Doherty Institute for Infection and Immunity)

  • Stephanie Gras

    (Biomedicine Discovery Institute, Monash University
    Monash University
    La Trobe Institute For Molecular Science, La Trobe University)

  • Jamie Rossjohn

    (Biomedicine Discovery Institute, Monash University
    Monash University
    Cardiff University School of Medicine, Heath Park)

  • Jane Crowe

    (Deepdene Surgery)

  • Jianqing Xu

    (Shanghai Medical College, Fudan University)

  • David Jackson

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Lorena E. Brown

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Nicole Gruta

    (Biomedicine Discovery Institute, Monash University)

  • Weisan Chen

    (La Trobe Institute For Molecular Science, La Trobe University)

  • Peter C. Doherty

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

  • Stephen J. Turner

    (Biomedicine Discovery Institute, Monash University)

  • Tom C. Kotsimbos

    (The Alfred Hospital
    The Alfred Hospital)

  • Paul G. Thomas

    (St Jude Children’s Research Hospital)

  • Allen C. Cheng

    (Monash University
    Alfred Health)

  • Katherine Kedzierska

    (University of Melbourne, at the Peter Doherty Institute for Infection and Immunity)

Abstract

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one single study. Here, we utilize longitudinal samples from patients hospitalized with acute influenza to understand these immune responses. We report the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels. Influenza disease correlates with increases in IL-6/IL-8/MIP-1α/β cytokines and lower antibody responses. Robust activation of circulating T follicular helper cells correlates with peak antibody-secreting cells and influenza heamaglutinin-specific memory B-cell numbers, which phenotypically differs from vaccination-induced B-cell responses. Numbers of influenza-specific CD8+ or CD4+ T cells increase early in disease and retain an activated phenotype during patient recovery. We report the characterisation of immune cellular networks underlying recovery from influenza infection which are highly relevant to other infectious diseases.

Suggested Citation

  • Thi H. O. Nguyen & Marios Koutsakos & Carolien E. Sandt & Jeremy Chase Crawford & Liyen Loh & Sneha Sant & Ludivine Grzelak & Emma K. Allen & Tim Brahm & E. Bridie Clemens & Maria Auladell & Luca Hens, 2021. "Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23018-x
    DOI: 10.1038/s41467-021-23018-x
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