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A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats

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  • D. S. Engelke

    (The University of Texas Health Science Center)

  • X. O. Zhang

    (The University of Texas Health Science Center)

  • J. J. O’Malley

    (The University of Texas Health Science Center)

  • J. A. Fernandez-Leon

    (The University of Texas Health Science Center)

  • S. Li

    (University of Manitoba)

  • G. J. Kirouac

    (University of Manitoba)

  • M. Beierlein

    (The University of Texas Health Science Center)

  • F. H. Do-Monte

    (The University of Texas Health Science Center)

Abstract

Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVTCRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVTCRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVTCRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats.

Suggested Citation

  • D. S. Engelke & X. O. Zhang & J. J. O’Malley & J. A. Fernandez-Leon & S. Li & G. J. Kirouac & M. Beierlein & F. H. Do-Monte, 2021. "A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22730-y
    DOI: 10.1038/s41467-021-22730-y
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    Cited by:

    1. Kelsey M. Vollmer & Lisa M. Green & Roger I. Grant & Kion T. Winston & Elizabeth M. Doncheck & Christopher W. Bowen & Jacqueline E. Paniccia & Rachel E. Clarke & Annika Tiller & Preston N. Siegler & B, 2022. "An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Kuikui Zhou & Hua Xu & Shanshan Lu & Shaolei Jiang & Guoqiang Hou & Xiaofei Deng & Miao He & Yingjie Zhu, 2022. "Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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