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The VRNetzer platform enables interactive network analysis in Virtual Reality

Author

Listed:
  • Sebastian Pirch

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna)

  • Felix Müller

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna)

  • Eugenia Iofinova

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences)

  • Julia Pazmandi

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna
    Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases)

  • Christiane V. R. Hütter

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna)

  • Martin Chiettini

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna)

  • Celine Sin

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna)

  • Kaan Boztug

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases
    St. Anna Children’s Cancer Research Institute (CCRI)
    St. Anna Children’s Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna)

  • Iana Podkosova

    (Institute of Visual Computing and Human-Centered Technology, TU Wien)

  • Hannes Kaufmann

    (Institute of Visual Computing and Human-Centered Technology, TU Wien)

  • Jörg Menche

    (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
    University of Vienna
    Faculty of Mathematics, University of Vienna)

Abstract

Networks provide a powerful representation of interacting components within complex systems, making them ideal for visually and analytically exploring big data. However, the size and complexity of many networks render static visualizations on typically-sized paper or screens impractical, resulting in proverbial ‘hairballs’. Here, we introduce a Virtual Reality (VR) platform that overcomes these limitations by facilitating the thorough visual, and interactive, exploration of large networks. Our platform allows maximal customization and extendibility, through the import of custom code for data analysis, integration of external databases, and design of arbitrary user interface elements, among other features. As a proof of concept, we show how our platform can be used to interactively explore genome-scale molecular networks to identify genes associated with rare diseases and understand how they might contribute to disease development. Our platform represents a general purpose, VR-based data exploration platform for large and diverse data types by providing an interface that facilitates the interaction between human intuition and state-of-the-art analysis methods.

Suggested Citation

  • Sebastian Pirch & Felix Müller & Eugenia Iofinova & Julia Pazmandi & Christiane V. R. Hütter & Martin Chiettini & Celine Sin & Kaan Boztug & Iana Podkosova & Hannes Kaufmann & Jörg Menche, 2021. "The VRNetzer platform enables interactive network analysis in Virtual Reality," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22570-w
    DOI: 10.1038/s41467-021-22570-w
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