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Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases

Author

Listed:
  • Yadi Chen

    (Fujian Agriculture and Forestry University)

  • Xiaohua Hu

    (Fujian Agriculture and Forestry University)

  • Siyuan Liu

    (Fujian Agriculture and Forestry University)

  • Tiantian Su

    (University of California)

  • Hsiaochi Huang

    (University of California)

  • Huibo Ren

    (Fujian Agriculture and Forestry University)

  • Zhensheng Gao

    (Fujian Agriculture and Forestry University)

  • Xu Wang

    (Fujian Agriculture and Forestry University
    University of California)

  • Deshu Lin

    (Fujian Agriculture and Forestry University)

  • James A. Wohlschlegel

    (University of California)

  • Qin Wang

    (Fujian Agriculture and Forestry University)

  • Chentao Lin

    (University of California)

Abstract

Cryptochromes (CRYs) are photoreceptors or components of the molecular clock in various evolutionary lineages, and they are commonly regulated by polyubiquitination and proteolysis. Multiple E3 ubiquitin ligases regulate CRYs in animal models, and previous genetics study also suggest existence of multiple E3 ubiquitin ligases for plant CRYs. However, only one E3 ligase, Cul4COP1/SPAs, has been reported for plant CRYs so far. Here we show that Cul3LRBs is the second E3 ligase of CRY2 in Arabidopsis. We demonstrate the blue light-specific and CRY-dependent activity of LRBs (Light-Response Bric-a-Brack/Tramtrack/Broad 1, 2 & 3) in blue-light regulation of hypocotyl elongation. LRBs physically interact with photoexcited and phosphorylated CRY2, at the CCE domain of CRY2, to facilitate polyubiquitination and degradation of CRY2 in response to blue light. We propose that Cul4COP1/SPAs and Cul3LRBs E3 ligases interact with CRY2 via different structure elements to regulate the abundance of CRY2 photoreceptor under different light conditions, facilitating optimal photoresponses of plants grown in nature.

Suggested Citation

  • Yadi Chen & Xiaohua Hu & Siyuan Liu & Tiantian Su & Hsiaochi Huang & Huibo Ren & Zhensheng Gao & Xu Wang & Deshu Lin & James A. Wohlschlegel & Qin Wang & Chentao Lin, 2021. "Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22410-x
    DOI: 10.1038/s41467-021-22410-x
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    Cited by:

    1. Yuqing He & Yingjun Yu & Xiling Wang & Yumei Qin & Chen Su & Lei Wang, 2022. "Aschoff’s rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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