IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-22397-5.html
   My bibliography  Save this article

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

Author

Listed:
  • Cheryl Q. E. Lee

    (Institute of Medical Biology, A*STAR)

  • Baptiste Kerouanton

    (Program in Cardiovascular and Metabolic Disorders)

  • Sonia Chothani

    (Program in Cardiovascular and Metabolic Disorders)

  • Shan Zhang

    (Program in Cardiovascular and Metabolic Disorders)

  • Ying Chen

    (Institute of Molecular and Cell Biology, A*STAR)

  • Chinmay Kumar Mantri

    (Program in Emerging Infectious Diseases)

  • Daniella Helena Hock

    (University of Melbourne)

  • Radiance Lim

    (Program in Cardiovascular and Metabolic Disorders)

  • Rhea Nadkarni

    (Program in Cardiovascular and Metabolic Disorders)

  • Vinh Thang Huynh

    (Institute of Molecular and Cell Biology, A*STAR
    Nanyang Technological University Singapore)

  • Daryl Lim

    (Genome Institute Singapore, A*STAR)

  • Wei Leong Chew

    (Genome Institute Singapore, A*STAR)

  • Franklin L. Zhong

    (Nanyang Technological University, Skin Diseases and Wound Repair Program
    Skin Research Institute of Singapore, A*STAR)

  • David Arthur Stroud

    (University of Melbourne)

  • Sebastian Schafer

    (Program in Cardiovascular and Metabolic Disorders
    National Heart Research Institute Singapore, National Heart Centre Singapore)

  • Vinay Tergaonkar

    (Institute of Molecular and Cell Biology, A*STAR
    National University of Singapore)

  • Ashley L. John

    (Program in Emerging Infectious Diseases
    National University of Singapore
    Duke University Medical Center)

  • Owen J. L. Rackham

    (Program in Cardiovascular and Metabolic Disorders)

  • Lena Ho

    (Institute of Medical Biology, A*STAR
    Program in Cardiovascular and Metabolic Disorders
    Institute of Molecular and Cell Biology, A*STAR)

Abstract

Mito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we screen for mito-SEPs that modify inflammatory outcomes and report a mito-SEP named “Modulator of cytochrome C oxidase during Inflammation” (MOCCI) that is upregulated during inflammation and infection to promote host-protective resolution. MOCCI, a paralog of the NDUFA4 subunit of cytochrome C oxidase (Complex IV), replaces NDUFA4 in Complex IV during inflammation to lower mitochondrial membrane potential and reduce ROS production, leading to cyto-protection and dampened immune response. The MOCCI transcript also generates miR-147b, which targets the NDUFA4 mRNA with similar immune dampening effects as MOCCI, but simultaneously enhances RIG-I/MDA-5-mediated viral immunity. Our work uncovers a dual-component pleiotropic regulation of host inflammation and immunity by MOCCI (C15ORF48) for safeguarding the host during infection and inflammation.

Suggested Citation

  • Cheryl Q. E. Lee & Baptiste Kerouanton & Sonia Chothani & Shan Zhang & Ying Chen & Chinmay Kumar Mantri & Daniella Helena Hock & Radiance Lim & Rhea Nadkarni & Vinh Thang Huynh & Daryl Lim & Wei Leong, 2021. "Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity," Nature Communications, Nature, vol. 12(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22397-5
    DOI: 10.1038/s41467-021-22397-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-22397-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-22397-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22397-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.