IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-22375-x.html
   My bibliography  Save this article

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Author

Listed:
  • Jake W. Rhodes

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Rachel A. Botting

    (The Westmead Institute for Medical Research
    The University of Sydney
    The University of Newcastle)

  • Kirstie M. Bertram

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Erica E. Vine

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Hafsa Rana

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Heeva Baharlou

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Peter Vegh

    (The University of Newcastle)

  • Thomas R. O’Neil

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Anneliese S. Ashhurst

    (The University of Sydney)

  • James Fletcher

    (The University of Newcastle)

  • Grant P. Parnell

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • J. Dinny Graham

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Najla Nasr

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Jake J. K. Lim

    (Dr Jake Lim PLC)

  • Laith Barnouti

    (Australia Plastic Surgery)

  • Peter Haertsch

    (Burns Unit, Concord Repatriation General Hospital)

  • Martijn P. Gosselink

    (The Westmead Institute for Medical Research
    Westmead Hospital)

  • Angelina Di Re

    (The Westmead Institute for Medical Research
    Westmead Hospital)

  • Faizur Reza

    (The Westmead Institute for Medical Research
    Westmead Hospital)

  • Grahame Ctercteko

    (The Westmead Institute for Medical Research
    Westmead Hospital)

  • Gregory J. Jenkins

    (Westmead Hospital)

  • Andrew J. Brooks

    (Westmead Hospital)

  • Ellis Patrick

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Scott N. Byrne

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Eric Hunter

    (Emory Vaccine Centre)

  • Muzlifah A. Haniffa

    (The University of Newcastle
    Wellcome Sanger Institute
    Newcastle Hospitals NHS Foundation Trust)

  • Anthony L. Cunningham

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Andrew N. Harman

    (The Westmead Institute for Medical Research
    The University of Sydney)

Abstract

Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies have focused on epithelial MNPs. However, as mucosal trauma and inflammation are now known to be strongly associated with HIV transmission, here we examine the role of sub-epithelial MNPs which are present in a diverse array of subsets. We show that HIV can penetrate the epithelial surface to interact with sub-epithelial resident MNPs in anogenital explants and define the full array of subsets that are present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission. In doing so we identify two subsets that preferentially take up HIV, become infected and transmit the virus to CD4 T cells; CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 (cDC2).

Suggested Citation

  • Jake W. Rhodes & Rachel A. Botting & Kirstie M. Bertram & Erica E. Vine & Hafsa Rana & Heeva Baharlou & Peter Vegh & Thomas R. O’Neil & Anneliese S. Ashhurst & James Fletcher & Grant P. Parnell & J. D, 2021. "Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22375-x
    DOI: 10.1038/s41467-021-22375-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-22375-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-22375-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chuan Shen & Yiyang Li & Boqian Wang & Zhipeng Zong & Tianfei Lu & Nokuzola Maboyi & Yuxiao Deng & Yongbing Qian & Jianjun Zhang & Xianting Ding & Qiang Xia, 2022. "HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22375-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.