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Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues

Author

Listed:
  • K. Venkatesan Iyer

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Max Planck Institute for the Physics of Complex Systems
    Indian Institute of Science)

  • Anna Taubenberger

    (Biotechnology Center TU Dresden)

  • Salma Ahmed Zeidan

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Natalie A. Dye

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Cluster of Excellence Physics of Life, TU Dresden)

  • Suzanne Eaton

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Cluster of Excellence Physics of Life, TU Dresden)

  • Frank Jülicher

    (Max Planck Institute for the Physics of Complex Systems
    Cluster of Excellence Physics of Life, TU Dresden
    Center for Systems Biology Dresden)

Abstract

The levels of nuclear protein Lamin A/C are crucial for nuclear mechanotransduction. Lamin A/C levels are known to scale with tissue stiffness and extracellular matrix levels in mesenchymal tissues. But in epithelial tissues, where cells lack a strong interaction with the extracellular matrix, it is unclear how Lamin A/C is regulated. Here, we show in epithelial tissues that Lamin A/C levels scale with apico-basal cell compression, independent of tissue stiffness. Using genetic perturbations in Drosophila epithelial tissues, we show that apico-basal cell compression regulates the levels of Lamin A/C by deforming the nucleus. Further, in mammalian epithelial cells, we show that nuclear deformation regulates Lamin A/C levels by modulating the levels of phosphorylation of Lamin A/C at Serine 22, a target for Lamin A/C degradation. Taken together, our results reveal a mechanism of Lamin A/C regulation which could provide key insights for understanding nuclear mechanotransduction in epithelial tissues.

Suggested Citation

  • K. Venkatesan Iyer & Anna Taubenberger & Salma Ahmed Zeidan & Natalie A. Dye & Suzanne Eaton & Frank Jülicher, 2021. "Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22010-9
    DOI: 10.1038/s41467-021-22010-9
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