IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-21993-9.html
   My bibliography  Save this article

The essential role of PRAK in tumor metastasis and its therapeutic potential

Author

Listed:
  • Yuqing Wang

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
    Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital)

  • Wei Wang

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Haoming Wu

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Yu Zhou

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Xiaodan Qin

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Yan Wang

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Jia Wu

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Xiu-Yuan Sun

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Yan Yang

    (Jinzhou Medical University)

  • Hui Xu

    (Jinzhou Medical University)

  • Xiaoping Qian

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Xuewen Pang

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Yan Li

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University))

  • Zhiqian Zhang

    (Peking University Cancer Hospital and Institute)

  • Jiahuai Han

    (Xiamen University)

  • Yu Zhang

    (Peking University. NHC Key Laboratory of Medical Immunology (Peking University)
    Jinzhou Medical University)

Abstract

Metastasis is the leading cause of cancer-related death. Despite the recent advancements in cancer treatment, there is currently no approved therapy for metastasis. The present study reveals a potent and selective activity of PRAK in the regulation of tumor metastasis. While showing no apparent effect on the growth of primary breast cancers or subcutaneously inoculated tumor lines, Prak deficiency abrogates lung metastases in PyMT mice or mice receiving intravenous injection of tumor cells. Consistently, PRAK expression is closely associated with metastatic risk in human cancers. Further analysis indicates that loss of function of PRAK leads to a pronounced inhibition of HIF-1α protein synthesis, possibly due to reduced mTORC1 activities. Notably, pharmacological inactivation of PRAK with a clinically relevant inhibitor recapitulates the anti-metastatic effect of Prak depletion, highlighting the therapeutic potential of targeting PRAK in the control of metastasis.

Suggested Citation

  • Yuqing Wang & Wei Wang & Haoming Wu & Yu Zhou & Xiaodan Qin & Yan Wang & Jia Wu & Xiu-Yuan Sun & Yan Yang & Hui Xu & Xiaoping Qian & Xuewen Pang & Yan Li & Zhiqian Zhang & Jiahuai Han & Yu Zhang, 2021. "The essential role of PRAK in tumor metastasis and its therapeutic potential," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21993-9
    DOI: 10.1038/s41467-021-21993-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-21993-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-21993-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21993-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.