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S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Author

Listed:
  • Joshua G. Liang

    (Clover Biopharmaceuticals)

  • Danmei Su

    (Clover Biopharmaceuticals)

  • Tian-Zhang Song

    (Chinese Academy of Sciences)

  • Yilan Zeng

    (Public Health Clinical Center of Chengdu)

  • Weijin Huang

    (National Institutes for Food and Drug Control (NIFDC))

  • Jinhua Wu

    (Clover Biopharmaceuticals)

  • Rong Xu

    (Clover Biopharmaceuticals)

  • Peiwen Luo

    (Clover Biopharmaceuticals)

  • Xiaofang Yang

    (Clover Biopharmaceuticals)

  • Xiaodong Zhang

    (Clover Biopharmaceuticals)

  • Shuangru Luo

    (Clover Biopharmaceuticals)

  • Ying Liang

    (Clover Biopharmaceuticals)

  • Xinglin Li

    (Clover Biopharmaceuticals)

  • Jiaju Huang

    (Clover Biopharmaceuticals)

  • Qiang Wang

    (Clover Biopharmaceuticals)

  • Xueqin Huang

    (Clover Biopharmaceuticals)

  • Qingsong Xu

    (Clover Biopharmaceuticals)

  • Mei Luo

    (Public Health Clinical Center of Chengdu)

  • Anliang Huang

    (Chengdu Fifth People’s Hospital)

  • Dongxia Luo

    (Public Health Clinical Center of Chengdu)

  • Chenyan Zhao

    (National Institutes for Food and Drug Control (NIFDC))

  • Fan Yang

    (Chengdu Fifth People’s Hospital)

  • Jian-Bao Han

    (Chinese Academy of Sciences)

  • Yong-Tang Zheng

    (Chinese Academy of Sciences)

  • Peng Liang

    (Clover Biopharmaceuticals)

Abstract

SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.

Suggested Citation

  • Joshua G. Liang & Danmei Su & Tian-Zhang Song & Yilan Zeng & Weijin Huang & Jinhua Wu & Rong Xu & Peiwen Luo & Xiaofang Yang & Xiaodong Zhang & Shuangru Luo & Ying Liang & Xinglin Li & Jiaju Huang & Q, 2021. "S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21634-1
    DOI: 10.1038/s41467-021-21634-1
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    Cited by:

    1. Cai He & Jingyun Yang & Weiqi Hong & Zimin Chen & Dandan Peng & Hong Lei & Aqu Alu & Xuemei He & Zhenfei Bi & Xiaohua Jiang & Guowen Jia & Yun Yang & Yanan Zhou & Wenhai Yu & Cong Tang & Qing Huang & , 2022. "A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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