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The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome

Author

Listed:
  • Camille Bourgneuf

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN)

  • Danielle Bailbé

    (UMR 8251, CNRS, F-75013)

  • Antonin Lamazière

    (Centre de Recherche Saint-Antoine (CRSA)
    Département PM2)

  • Charlotte Dupont

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN
    Service de biologie de la reproduction-CECOS)

  • Marthe Moldes

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN)

  • Dominique Farabos

    (Centre de Recherche Saint-Antoine (CRSA)
    Département PM2)

  • Natacha Roblot

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN)

  • Camille Gauthier

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN)

  • Emmanuelle Mathieu d’Argent

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN
    Service de biologie de la reproduction-CECOS)

  • Joelle Cohen-Tannoudji

    (UMR 8251, CNRS, F-75013)

  • Danielle Monniaux

    (IFCE)

  • Bruno Fève

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN
    Service Endocrinologie, CRMR PRISIS)

  • Jamileh Movassat

    (UMR 8251, CNRS, F-75013)

  • Nathalie di Clemente

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN)

  • Chrystèle Racine

    (Centre de Recherche Saint-Antoine (CRSA)
    Institut Hospitalo-Universitaire ICAN
    Université de Paris)

Abstract

Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulate naturally all the reproductive and metabolic hallmarks of lean women with PCOS at puberty and in adulthood. The analysis of their gestation and of their fetuses demonstrates that this PCOS-like phenotype is developmentally programmed. GK rats also develop features of ovarian hyperstimulation syndrome. Lastly, a comparison between GK rats and a cohort of women with PCOS reveals a similar reproductive signature. Thus, this spontaneous rodent model of PCOS represents an original tool for the identification of the mechanisms involved in its pathogenesis and for the development of novel strategies for its treatment.

Suggested Citation

  • Camille Bourgneuf & Danielle Bailbé & Antonin Lamazière & Charlotte Dupont & Marthe Moldes & Dominique Farabos & Natacha Roblot & Camille Gauthier & Emmanuelle Mathieu d’Argent & Joelle Cohen-Tannoudj, 2021. "The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21308-y
    DOI: 10.1038/s41467-021-21308-y
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