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Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Author

Listed:
  • Minh-Phuong Huynh-Le

    (University of California San Diego
    University of California San Diego)

  • Chun Chieh Fan

    (University of California San Diego)

  • Roshan Karunamuni

    (University of California San Diego
    University of California San Diego)

  • Wesley K. Thompson

    (University of California San Diego
    University of California San Diego)

  • Maria Elena Martinez

    (Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego)

  • Rosalind A. Eeles

    (The Institute of Cancer Research
    Royal Marsden NHS Foundation Trust)

  • Zsofia Kote-Jarai

    (The Institute of Cancer Research)

  • Kenneth Muir

    (University of Manchester, Oxford Road
    University of Warwick)

  • Johanna Schleutker

    (Kiinamyllynkatu 10, FI-20014 University of Turku
    Turku University Hospital)

  • Nora Pashayan

    (University College London, Department of Applied Health Research
    University of Cambridge, Strangeways Laboratory, Worts Causeway
    University College London)

  • Jyotsna Batra

    (Queensland University of Technology
    Translational Research Institute)

  • Henrik Grönberg

    (Karolinska Institute)

  • David E. Neal

    (University of Oxford, John Radcliffe Hospital
    University of Cambridge, Addenbrooke’s Hospital
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre)

  • Jenny L. Donovan

    (Bristol Medical School, University of Bristol)

  • Freddie C. Hamdy

    (University of Oxford
    University of Oxford, John Radcliffe Hospital)

  • Richard M. Martin

    (Bristol Medical School, University of Bristol
    University of Bristol
    University of Bristol)

  • Sune F. Nielsen

    (University of Copenhagen
    Copenhagen University Hospital)

  • Børge G. Nordestgaard

    (University of Copenhagen
    Copenhagen University Hospital)

  • Fredrik Wiklund

    (Karolinska Institute)

  • Catherine M. Tangen

    (Fred Hutchinson Cancer Research Center)

  • Graham G. Giles

    (Cancer Council Victoria
    The University of Melbourne
    Monash University)

  • Alicja Wolk

    (Karolinska Institutet
    Uppsala University)

  • Demetrius Albanes

    (National Cancer Institute, NIH)

  • Ruth C. Travis

    (University of Oxford)

  • William J. Blot

    (Vanderbilt University Medical Center
    International Epidemiology Institute)

  • Wei Zheng

    (Vanderbilt University Medical Center)

  • Maureen Sanderson

    (Meharry Medical College)

  • Janet L. Stanford

    (Fred Hutchinson Cancer Research Center
    School of Public Health, University of Washington)

  • Lorelei A. Mucci

    (Harvard T. H. Chan School of Public Health)

  • Catharine M. L. West

    (University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust)

  • Adam S. Kibel

    (Brigham and Womens Hospital)

  • Olivier Cussenot

    (Tenon Hospital, 4 Rue de la Chine
    CeRePP, Tenon Hospital)

  • Sonja I. Berndt

    (National Cancer Institute, NIH)

  • Stella Koutros

    (National Cancer Institute, NIH)

  • Karina Dalsgaard Sørensen

    (Aarhus University Hospital
    Aarhus University)

  • Cezary Cybulski

    (Pomeranian Medical University)

  • Eli Marie Grindedal

    (Oslo University Hospital)

  • Florence Menegaux

    (University Paris-Sud, University Paris-Saclay
    Paris-Sud University, UMRS 1018)

  • Kay-Tee Khaw

    (Clinical Gerontology Unit, University of Cambridge)

  • Jong Y. Park

    (Moffitt Cancer Center)

  • Sue A. Ingles

    (University of Southern California/Norris Comprehensive Cancer Center)

  • Christiane Maier

    (Humangenetik Tuebingen)

  • Robert J. Hamilton

    (Princess Margaret Cancer Centre
    University of Toronto)

  • Stephen N. Thibodeau

    (Mayo Clinic)

  • Barry S. Rosenstein

    (Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place
    Icahn School of Medicine at Mount Sinai)

  • Yong-Jie Lu

    (Queen Mary University of London, John Vane Science Centre, Charterhouse Square)

  • Stephen Watya

    (Uro Care)

  • Ana Vega

    (Fundación Pública Galega Medicina Xenómica
    Instituto de Investigación Sanitaria de Santiago de Compostela
    Centro de Investigación en Red de Enfermedades Raras (CIBERER))

  • Manolis Kogevinas

    (ISGlobal
    IMIM (Hospital del Mar Medical Research Institute)
    Universitat Pompeu Fabra (UPF))

  • Kathryn L. Penney

    (Brigham and Women’s Hospital/Harvard Medical School)

  • Chad Huff

    (The University of Texas M. D. Anderson Cancer Center)

  • Manuel R. Teixeira

    (Portuguese Oncology Institute of Porto (IPO-Porto)
    University of Porto)

  • Luc Multigner

    (Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)—UMR_S 1085)

  • Robin J. Leach

    (University of Texas Health Science Center at San Antonio)

  • Lisa Cannon-Albright

    (University of Utah School of Medicine
    George E. Wahlen Department of Veterans Affairs Medical Center)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460)

  • Esther M. John

    (Stanford University School of Medicine)

  • Radka Kaneva

    (Medical University of Sofia)

  • Christopher J. Logothetis

    (The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology)

  • Susan L. Neuhausen

    (Beckman Research Institute of the City of Hope)

  • Kim De Ruyck

    (Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences)

  • Hardev Pandha

    (The University of Surrey)

  • Azad Razack

    (University of Malaya)

  • Lisa F. Newcomb

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Jay H. Fowke

    (Vanderbilt University Medical Center
    The University of Tennessee Health Science Center)

  • Marija Gamulin

    (University Hospital Centre Zagreb, University of Zagreb, School of Medicine)

  • Nawaid Usmani

    (University of Alberta
    Cross Cancer Institute)

  • Frank Claessens

    (Molecular Endocrinology Laboratory, KU Leuven)

  • Manuela Gago-Dominguez

    (Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS
    University of California San Diego, Moores Cancer Center)

  • Paul A. Townsend

    (Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester)

  • William S. Bush

    (Cleveland Institute for Computational Biology)

  • Monique J. Roobol

    (Erasmus University Medical Center)

  • Marie-Élise Parent

    (Institut National de la Recherche Scientifique
    University of Montreal)

  • Jennifer J. Hu

    (Sylvester Comprehensive Cancer Center)

  • Ian G. Mills

    (University of Oxford)

  • Ole A. Andreassen

    (Oslo University Hospital and University of Oslo)

  • Anders M. Dale

    (University of California San Diego
    University of California San Diego)

  • Tyler M. Seibert

    (University of California San Diego
    University of California San Diego
    University of California San Diego
    University of California San Diego)

Abstract

Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p

Suggested Citation

  • Minh-Phuong Huynh-Le & Chun Chieh Fan & Roshan Karunamuni & Wesley K. Thompson & Maria Elena Martinez & Rosalind A. Eeles & Zsofia Kote-Jarai & Kenneth Muir & Johanna Schleutker & Nora Pashayan & Jyot, 2021. "Polygenic hazard score is associated with prostate cancer in multi-ethnic populations," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21287-0
    DOI: 10.1038/s41467-021-21287-0
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