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ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Author

Listed:
  • Hayley I. Muendlein

    (Tufts University School of Medicine)

  • Wilson M. Connolly

    (Tufts University School of Medicine)

  • Zoie Magri

    (Tufts University School of Medicine)

  • Irina Smirnova

    (Tufts University School of Medicine)

  • Vladimir Ilyukha

    (Petrozavodsk State Ulniversity)

  • Avishekh Gautam

    (Blood Cell Development and Function Program, Fox Chase Cancer Center)

  • Alexei Degterev

    (Tufts University School of Medicine)

  • Alexander Poltorak

    (Tufts University School of Medicine
    Petrozavodsk State Ulniversity)

Abstract

Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly regulated transition from TNFR1-associated pro-inflammatory complex I to pro-death complex II. By contrast, here we show that a TRIF-dependent complex containing FADD, RIPK1 and caspase-8 (that we have termed the TRIFosome) mediates cell death in response to Yersinia pseudotuberculosis and LPS. Furthermore, we show that constitutive binding between ZBP1 and RIPK1 is essential for the initiation of TRIFosome interactions, caspase-8-mediated cell death and inflammasome activation, thus positioning ZBP1 as an effector of cell death in the context of bacterial blockade of pro-inflammatory signaling. Additionally, our findings offer an alternative to the TNFR1-dependent model of complex II assembly, by demonstrating pro-death complex formation reliant on TRIF signaling.

Suggested Citation

  • Hayley I. Muendlein & Wilson M. Connolly & Zoie Magri & Irina Smirnova & Vladimir Ilyukha & Avishekh Gautam & Alexei Degterev & Alexander Poltorak, 2021. "ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20357-z
    DOI: 10.1038/s41467-020-20357-z
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