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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients

Author

Listed:
  • Yongliang Zhang

    (Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital)

  • Yu Yao

    (The First Affiliated Hospital of Xi’an Jiaotong University)

  • Yaping Xu

    (Geneplus-Beijing Institute)

  • Lifeng Li

    (Geneplus-Beijing Institute)

  • Yan Gong

    (Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital)

  • Kai Zhang

    (National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Meng Zhang

    (Peking University Cancer Hospital & Institute)

  • Yanfang Guan

    (Geneplus-Beijing Institute)

  • Lianpeng Chang

    (Geneplus-Beijing Institute)

  • Xuefeng Xia

    (Geneplus-Beijing Institute)

  • Lin Li

    (Beijing Hospital, National Center of Gerontology
    Institute of Geriatric Medicine, Chinese Academy of Medical Sciences)

  • Shuqin Jia

    (Peking University Cancer Hospital & Institute)

  • Qiang Zeng

    (Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital)

Abstract

Circulating tumor DNA (ctDNA) provides a noninvasive approach to elucidate a patient’s genomic landscape and actionable information. Here, we design a ctDNA-based study of over 10,000 pan-cancer Chinese patients. Using parallel sequencing between plasma and white blood cells, 14% of plasma cell-free DNA samples contain clonal hematopoiesis (CH) variants, for which detectability increases with age. After eliminating CH variants, ctDNA is detected in 73.5% of plasma samples, with small cell lung cancer (91.1%) and prostate cancer (87.9%) showing the highest detectability. The landscape of putative driver genes revealed by ctDNA profiling is similar to that in a tissue-based database (R2 = 0.87, p

Suggested Citation

  • Yongliang Zhang & Yu Yao & Yaping Xu & Lifeng Li & Yan Gong & Kai Zhang & Meng Zhang & Yanfang Guan & Lianpeng Chang & Xuefeng Xia & Lin Li & Shuqin Jia & Qiang Zeng, 2021. "Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20162-8
    DOI: 10.1038/s41467-020-20162-8
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    Cited by:

    1. Pei-Fen Zhang & Zi-Yi Wu & Wen-Bin Zhang & Yong-Qiao He & Kexin Chen & Tong-Min Wang & Haixin Li & Hong Zheng & Dan-Hua Li & Da-Wei Yang & Ting Zhou & Chang-Mi Deng & Ying Liao & Wen-Qiong Xue & Lian-, 2023. "Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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