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Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

Author

Listed:
  • Maria Jesús García-Murria

    (Universitat de València)

  • Gerard Duart

    (Universitat de València)

  • Brayan Grau

    (Universitat de València)

  • Elisabet Diaz-Beneitez

    (Campus Universidad Autónoma)

  • Dolores Rodríguez

    (Campus Universidad Autónoma)

  • Ismael Mingarro

    (Universitat de València)

  • Luis Martínez-Gil

    (Universitat de València)

Abstract

Viral control of programmed cell death relies in part on the expression of viral analogs of the B-cell lymphoma 2 (Bcl2) protein known as viral Bcl2s (vBcl2s). vBcl2s control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, we show that the carboxyl-terminal hydrophobic region of herpesviral and poxviral vBcl2s can operate as transmembrane domains (TMDs) and participate in their homo-oligomerization. Additionally, we show that the viral TMDs mediate interactions with cellular pro- and anti-apoptotic Bcl2 TMDs within the membrane. Furthermore, these intra-membrane interactions among viral and cellular proteins are necessary to control cell death upon an apoptotic stimulus. Therefore, their inhibition represents a new potential therapy against viral infections, which are characterized by short- and long-term deregulation of programmed cell death.

Suggested Citation

  • Maria Jesús García-Murria & Gerard Duart & Brayan Grau & Elisabet Diaz-Beneitez & Dolores Rodríguez & Ismael Mingarro & Luis Martínez-Gil, 2020. "Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19881-9
    DOI: 10.1038/s41467-020-19881-9
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