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Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease

Author

Listed:
  • Kate L. Bowerman

    (The University of Queensland)

  • Saima Firdous Rehman

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle)

  • Annalicia Vaughan

    (Thoracic Research Centre, Faculty of Medicine, The University of Queensland, and Department of Thoracic Medicine, The Prince Charles Hospital)

  • Nancy Lachner

    (The University of Queensland)

  • Kurtis F. Budden

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle)

  • Richard Y. Kim

    (Centre for Inflammation, Centenary Institute & University of Technology Sydney, School of Life Sciences, Faculty of Science)

  • David L. A. Wood

    (The University of Queensland)

  • Shaan L. Gellatly

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle)

  • Shakti D. Shukla

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle)

  • Lisa G. Wood

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle)

  • Ian A. Yang

    (Thoracic Research Centre, Faculty of Medicine, The University of Queensland, and Department of Thoracic Medicine, The Prince Charles Hospital)

  • Peter A. Wark

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle)

  • Philip Hugenholtz

    (The University of Queensland)

  • Philip M. Hansbro

    (Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, and The University of Newcastle
    Centre for Inflammation, Centenary Institute & University of Technology Sydney, School of Life Sciences, Faculty of Science)

Abstract

Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445, Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.

Suggested Citation

  • Kate L. Bowerman & Saima Firdous Rehman & Annalicia Vaughan & Nancy Lachner & Kurtis F. Budden & Richard Y. Kim & David L. A. Wood & Shaan L. Gellatly & Shakti D. Shukla & Lisa G. Wood & Ian A. Yang &, 2020. "Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19701-0
    DOI: 10.1038/s41467-020-19701-0
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    Cited by:

    1. Yongzhi Yang & Lutao Du & Debing Shi & Cheng Kong & Jianqiang Liu & Guang Liu & Xinxiang Li & Yanlei Ma, 2021. "Dysbiosis of human gut microbiome in young-onset colorectal cancer," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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