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Concepts of extracellular matrix remodelling in tumour progression and metastasis

Author

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  • Juliane Winkler

    (University of California)

  • Abisola Abisoye-Ogunniyan

    (University of California)

  • Kevin J. Metcalf

    (University of California)

  • Zena Werb

    (University of California)

Abstract

Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.

Suggested Citation

  • Juliane Winkler & Abisola Abisoye-Ogunniyan & Kevin J. Metcalf & Zena Werb, 2020. "Concepts of extracellular matrix remodelling in tumour progression and metastasis," Nature Communications, Nature, vol. 11(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18794-x
    DOI: 10.1038/s41467-020-18794-x
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    6. Connor Stashko & Mary-Kate Hayward & Jason J. Northey & Neil Pearson & Alastair J. Ironside & Johnathon N. Lakins & Roger Oria & Marie-Anne Goyette & Lakyn Mayo & Hege G. Russnes & E. Shelley Hwang & , 2023. "A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
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