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Ultralong purely organic aqueous phosphorescence supramolecular polymer for targeted tumor cell imaging

Author

Listed:
  • Wei-Lei Zhou

    (Nankai University)

  • Yong Chen

    (Nankai University)

  • Qilin Yu

    (Nankai University
    College of Life Sciences, Nankai University)

  • Haoyang Zhang

    (Nankai University)

  • Zhi-Xue Liu

    (Nankai University)

  • Xian-Yin Dai

    (Nankai University)

  • Jing-Jing Li

    (Nankai University)

  • Yu Liu

    (Nankai University)

Abstract

Purely organic room-temperature phosphorescence has attracted attention for bioimaging but can be quenched in aqueous systems. Here we report a water-soluble ultralong organic room-temperature phosphorescent supramolecular polymer by combining cucurbit[n]uril (CB[7], CB[8]) and hyaluronic acid (HA) as a tumor-targeting ligand conjugated to a 4-(4-bromophenyl)pyridin-1-ium bromide (BrBP) phosphor. The result shows that CB[7] mediated pseudorotaxane polymer CB[7]/HA–BrBP changes from small spherical aggregates to a linear array, whereas complexation with CB[8] results in biaxial pseudorotaxane polymer CB[8]/HA–BrBP which transforms to relatively large aggregates. Owing to the more stable 1:2 inclusion complex between CB[8] and BrBP and the multiple hydrogen bonds, this supramolecular polymer has ultralong purely organic RTP lifetime in water up to 4.33 ms with a quantum yield of 7.58%. Benefiting from the targeting property of HA, this supramolecular polymer is successfully applied for cancer cell targeted phosphorescence imaging of mitochondria.

Suggested Citation

  • Wei-Lei Zhou & Yong Chen & Qilin Yu & Haoyang Zhang & Zhi-Xue Liu & Xian-Yin Dai & Jing-Jing Li & Yu Liu, 2020. "Ultralong purely organic aqueous phosphorescence supramolecular polymer for targeted tumor cell imaging," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18520-7
    DOI: 10.1038/s41467-020-18520-7
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    Cited by:

    1. Xiaoyu Chen & Renlong Zhu & Baicheng Zhang & Xiaolong Zhang & Aoyuan Cheng & Hongping Liu & Ruiying Gao & Xuepeng Zhang & Biao Chen & Shuji Ye & Jun Jiang & Guoqing Zhang, 2024. "Rapid room-temperature phosphorescence chiral recognition of natural amino acids," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Qingao Chen & Lunjun Qu & Hui Hou & Jiayue Huang & Chen Li & Ying Zhu & Yongkang Wang & Xiaohong Chen & Qian Zhou & Yan Yang & Chaolong Yang, 2024. "Long lifetimes white afterglow in slightly crosslinked polymer systems," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Yinglong Wu & Lihe Sun & Xiaokai Chen & Jiawei Liu & Juan Ouyang & Xiaodong Zhang & Yi Guo & Yun Chen & Wei Yuan & Dongdong Wang & Ting He & Fang Zeng & Hongzhong Chen & Shuizhu Wu & Yanli Zhao, 2023. "Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Xiao Wang & Wenjing Sun & Huifang Shi & Huili Ma & Guowei Niu & Yuxin Li & Jiahuan Zhi & Xiaokang Yao & Zhicheng Song & Lei Chen & Shi Li & Guohui Yang & Zixing Zhou & Yixiao He & Shuli Qu & Min Wu & , 2022. "Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. Wenping Zhu & Ying Li & Shaoxun Guo & Wu-Jie Guo & Tuokai Peng & Hui Li & Bin Liu & Hui-Qing Peng & Ben Zhong Tang, 2022. "Stereoisomeric engineering of aggregation-induced emission photosensitizers towards fungal killing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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