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A shared genetic contribution to breast cancer and schizophrenia

Author

Listed:
  • Donghao Lu

    (Karolinska Institutet
    Harvard Medical School
    Harvard T.H. Chan School of Public Health)

  • Jie Song

    (Karolinska Institutet)

  • Yi Lu

    (Karolinska Institutet)

  • Katja Fall

    (Örebro University)

  • Xu Chen

    (Karolinska Institutet)

  • Fang Fang

    (Karolinska Institutet)

  • Mikael Landén

    (Karolinska Institutet
    The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital)

  • Christina M. Hultman

    (Karolinska Institutet
    Icahn School of Medicine, Mt. Sinai Hospital)

  • Kamila Czene

    (Karolinska Institutet)

  • Patrick Sullivan

    (Karolinska Institutet
    University of North Carolina)

  • Rulla M. Tamimi

    (Harvard Medical School
    Harvard T.H. Chan School of Public Health
    Weill Cornell Medicine)

  • Unnur A. Valdimarsdóttir

    (Karolinska Institutet
    Harvard T.H. Chan School of Public Health
    University of Iceland)

Abstract

An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.

Suggested Citation

  • Donghao Lu & Jie Song & Yi Lu & Katja Fall & Xu Chen & Fang Fang & Mikael Landén & Christina M. Hultman & Kamila Czene & Patrick Sullivan & Rulla M. Tamimi & Unnur A. Valdimarsdóttir, 2020. "A shared genetic contribution to breast cancer and schizophrenia," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18492-8
    DOI: 10.1038/s41467-020-18492-8
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