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Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection

Author

Listed:
  • Nitesh Mishra

    (All India Institute of Medical Sciences)

  • Shaifali Sharma

    (All India Institute of Medical Sciences)

  • Ayushman Dobhal

    (All India Institute of Medical Sciences)

  • Sanjeev Kumar

    (All India Institute of Medical Sciences
    ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology)

  • Himanshi Chawla

    (All India Institute of Medical Sciences
    University of Southampton)

  • Ravinder Singh

    (All India Institute of Medical Sciences)

  • Muzamil Ashraf Makhdoomi

    (All India Institute of Medical Sciences
    Cluster University Srinagar)

  • Bimal Kumar Das

    (All India Institute of Medical Sciences)

  • Rakesh Lodha

    (All India Institute of Medical Sciences)

  • Sushil Kumar Kabra

    (All India Institute of Medical Sciences)

  • Kalpana Luthra

    (All India Institute of Medical Sciences)

Abstract

Broadly neutralizing antibodies (bnAbs) develop in a subset of HIV-1 infected individuals over 2–3 years of infection. Infected infants develop plasma bnAbs frequently and as early as 1-year post-infection suggesting factors governing bnAb induction in infants are distinct from adults. Understanding viral characteristics in infected infants with early bnAb responses will provide key information about antigenic triggers driving B cell maturation pathways towards induction of bnAbs. Herein, we evaluate the presence of plasma bnAbs in a cohort of 51 HIV-1 clade-C infected infants and identify viral factors associated with early bnAb responses. Plasma bnAbs targeting V2-apex on the env are predominant in infant elite and broad neutralizers. Circulating viral variants in infant elite neutralizers are susceptible to V2-apex bnAbs. In infant elite neutralizers, multivariant infection is associated with plasma bnAbs targeting diverse autologous viruses. Our data provides information supportive of polyvalent vaccination approaches capable of inducing V2-apex bnAbs against HIV-1.

Suggested Citation

  • Nitesh Mishra & Shaifali Sharma & Ayushman Dobhal & Sanjeev Kumar & Himanshi Chawla & Ravinder Singh & Muzamil Ashraf Makhdoomi & Bimal Kumar Das & Rakesh Lodha & Sushil Kumar Kabra & Kalpana Luthra, 2020. "Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18225-x
    DOI: 10.1038/s41467-020-18225-x
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