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A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

Author

Listed:
  • Shipo Wu

    (Beijing Institute of Biotechnology)

  • Gongxun Zhong

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Jun Zhang

    (Beijing Institute of Biotechnology)

  • Lei Shuai

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Zhe Zhang

    (Beijing Institute of Biotechnology)

  • Zhiyuan Wen

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Busen Wang

    (Beijing Institute of Biotechnology)

  • Zhenghao Zhao

    (Beijing Institute of Biotechnology)

  • Xiaohong Song

    (Beijing Institute of Biotechnology)

  • Yi Chen

    (Beijing Institute of Biotechnology)

  • Renqiang Liu

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Ling Fu

    (Beijing Institute of Biotechnology)

  • Jinlong Zhang

    (Beijing Institute of Biotechnology)

  • Qiang Guo

    (Beijing Institute of Biotechnology)

  • Chong Wang

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Yilong Yang

    (Beijing Institute of Biotechnology)

  • Ting Fang

    (Beijing Institute of Biotechnology)

  • Peng Lv

    (Beijing Institute of Biotechnology)

  • Jinliang Wang

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Junjie Xu

    (Beijing Institute of Biotechnology)

  • Jianmin Li

    (Beijing Institute of Biotechnology)

  • Changming Yu

    (Beijing Institute of Biotechnology)

  • Lihua Hou

    (Beijing Institute of Biotechnology)

  • Zhigao Bu

    (State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute)

  • Wei Chen

    (Beijing Institute of Biotechnology)

Abstract

The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.

Suggested Citation

  • Shipo Wu & Gongxun Zhong & Jun Zhang & Lei Shuai & Zhe Zhang & Zhiyuan Wen & Busen Wang & Zhenghao Zhao & Xiaohong Song & Yi Chen & Renqiang Liu & Ling Fu & Jinlong Zhang & Qiang Guo & Chong Wang & Yi, 2020. "A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17972-1
    DOI: 10.1038/s41467-020-17972-1
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