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Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus

Author

Listed:
  • Kyeonghye Guk

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB)
    University of Science and Technology (UST))

  • Hyeran Kim

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB))

  • Miyeon Lee

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Yoon-Aa Choi

    (BioNano Health Guard Research Center, KRIBB)

  • Seul Gee Hwang

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB)
    University of Science and Technology (UST))

  • Gaon Han

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB)
    University of Science and Technology (UST))

  • Hye-Nan Kim

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB))

  • Hongki Kim

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB))

  • Hwangseo Park

    (Sejong University)

  • Dongeun Yong

    (Yonsei University College of Medicine)

  • Taejoon Kang

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB))

  • Eun-Kyung Lim

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB)
    University of Science and Technology (UST))

  • Juyeon Jung

    (Korea Research Institute of Bioscience & Biotechnology (KRIBB)
    University of Science and Technology (UST))

Abstract

The emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant I223R/H275Y neuraminidase and prove the applicability of A4 antibody for direct detection of antiviral multidrug-resistant viruses in various sensing platforms, including naked-eye detection, surface-enhanced Raman scattering-based immunoassay, and lateral flow system. The development of the A4 antibody enables fast, simple, and reliable point-of-care assays of antiviral multidrug-resistant influenza viruses. In addition to current influenza virus infection testing methods that do not provide information on the antiviral drug-resistance of the virus, diagnostic tests for antiviral multidrug-resistant viruses will improve clinical judgment in the treatment of influenza virus infections, avoid the unnecessary prescription of ineffective drugs, and improve current therapies.

Suggested Citation

  • Kyeonghye Guk & Hyeran Kim & Miyeon Lee & Yoon-Aa Choi & Seul Gee Hwang & Gaon Han & Hye-Nan Kim & Hongki Kim & Hwangseo Park & Dongeun Yong & Taejoon Kang & Eun-Kyung Lim & Juyeon Jung, 2020. "Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17246-w
    DOI: 10.1038/s41467-020-17246-w
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