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Blood genome expression profiles in infants with congenital cytomegalovirus infection

Author

Listed:
  • Christopher P. Ouellette

    (Nationwide Children’s Hospital –The Ohio State University College of Medicine)

  • Pablo J. Sánchez

    (Nationwide Children’s Hospital –The Ohio State University College of Medicine
    Nationwide Children’s Hospital–The Ohio State University College of Medicine
    Abigail Wexner Research Institute at Nationwide Children’s Hospital
    University of Texas Southwestern Medical Center)

  • Zhaohui Xu

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Derek Blankenship

    (DB Analytics LLC)

  • Fiker Zeray

    (Children’s Medical Center Dallas)

  • Andrea Ronchi

    (University of Texas Southwestern Medical Center
    Fondazione IRCCS, Ca’ Granda Ospedale Maggiore Policlinico)

  • Masako Shimamura

    (Nationwide Children’s Hospital –The Ohio State University College of Medicine
    Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Damien Chaussabel

    (Sidra Medical and Research Center)

  • Lizette Lee

    (University of Texas Southwestern Medical Center
    Children’s Medical Center Dallas)

  • Kris E. Owen

    (Children’s Medical Center Dallas
    University of Texas Southwestern Medical Center)

  • Angela G. Shoup

    (University of Texas Southwestern Medical Center
    Parkland Health and Hospital System)

  • Octavio Ramilo

    (Nationwide Children’s Hospital –The Ohio State University College of Medicine
    Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Asuncion Mejias

    (Nationwide Children’s Hospital –The Ohio State University College of Medicine
    Abigail Wexner Research Institute at Nationwide Children’s Hospital)

Abstract

Congenital CMV infection (cCMVi) affects 0.5–1% of all live births worldwide, making it the leading cause of sensorineural hearing loss (SNHL) in childhood. The majority of infants with cCMVi have normal hearing at birth, but are at risk of developing late-onset SNHL. Currently, we lack reliable biomarkers to predict the development of SNHL in these infants. Here, we evaluate blood transcriptional profiles in 80 infants with cCMVi (49 symptomatic, 31 asymptomatic), enrolled in the first 3 weeks of life, and followed for 3 years to assess emergence of late-onset SNHL. The biosignatures of symptomatic and asymptomatic cCMVi are indistinguishable, suggesting that immune responses of infants with asymptomatic and symptomatic cCMVi are not different. Random forest analyses of initial samples in infants with cCMVi, irrespective of their clinical classification, identify a 16-gene classifier signature associated with the development of SNHL with 92% accuracy, suggesting its potential value as a biomarker.

Suggested Citation

  • Christopher P. Ouellette & Pablo J. Sánchez & Zhaohui Xu & Derek Blankenship & Fiker Zeray & Andrea Ronchi & Masako Shimamura & Damien Chaussabel & Lizette Lee & Kris E. Owen & Angela G. Shoup & Octav, 2020. "Blood genome expression profiles in infants with congenital cytomegalovirus infection," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17178-5
    DOI: 10.1038/s41467-020-17178-5
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