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A flexible and physically transient electrochemical sensor for real-time wireless nitric oxide monitoring

Author

Listed:
  • Rongfeng Li

    (Tsinghua University)

  • Hui Qi

    (Beijing Institute of Traumatology and Orthopaedics)

  • Yuan Ma

    (Tsinghua University)

  • Yuping Deng

    (Tsinghua University)

  • Shengnan Liu

    (Tsinghua University)

  • Yongsheng Jie

    (Beijing Institute of Traumatology and Orthopaedics)

  • Jinzhu Jing

    (Beijing Institute of Traumatology and Orthopaedics)

  • Jinlong He

    (Tianjin Medical University)

  • Xu Zhang

    (Tianjin Medical University)

  • Laura Wheatley

    (University of Oxford)

  • Congxi Huang

    (Tsinghua University)

  • Xing Sheng

    (Tsinghua University)

  • Milin Zhang

    (Tsinghua University)

  • Lan Yin

    (Tsinghua University)

Abstract

Real-time sensing of nitric oxide (NO) in physiological environments is critically important in monitoring neurotransmission, inflammatory responses, cardiovascular systems, etc. Conventional approaches for NO detection relying on indirect colorimetric measurement or built with rigid and permanent materials cannot provide continuous monitoring and/or require additional surgical retrieval of the implants, which comes with increased risks and hospital cost. Herein, we report a flexible, biologically degradable and wirelessly operated electrochemical sensor for real-time NO detection with a low detection limit (3.97 nmol), a wide sensing range (0.01–100 μM), and desirable anti-interference characteristics. The device successfully captures NO evolution in cultured cells and organs, with results comparable to those obtained from the standard Griess assay. Incorporated with a wireless circuit, the sensor platform achieves continuous sensing of NO levels in living mammals for several days. The work may provide essential diagnostic and therapeutic information for health assessment, treatment optimization and postsurgical monitoring.

Suggested Citation

  • Rongfeng Li & Hui Qi & Yuan Ma & Yuping Deng & Shengnan Liu & Yongsheng Jie & Jinzhu Jing & Jinlong He & Xu Zhang & Laura Wheatley & Congxi Huang & Xing Sheng & Milin Zhang & Lan Yin, 2020. "A flexible and physically transient electrochemical sensor for real-time wireless nitric oxide monitoring," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17008-8
    DOI: 10.1038/s41467-020-17008-8
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