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Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Author

Listed:
  • Eva Hadadi

    (Université Paris Sud)

  • William Taylor

    (Université Paris Sud)

  • Xiao-Mei Li

    (Université Paris Sud
    Université Paris Sud, Université Paris Saclay, UFR de Médecine Kremlin Bicêtre)

  • Yetki Aslan

    (Université Paris Diderot, Hôpital Lariboisière - Centre Viggo Petersen)

  • Marthe Villote

    (Université Paris-Saclay)

  • Julie Rivière

    (Université Paris-Saclay)

  • Gaelle Duvallet

    (Inserm)

  • Charlotte Auriau

    (Inserm)

  • Sandrine Dulong

    (Université Paris Sud
    Université Paris Sud, Université Paris Saclay, UFR de Médecine Kremlin Bicêtre)

  • Isabelle Raymond-Letron

    (Université de Toulouse
    Université de Toulouse)

  • Sylvain Provot

    (Université Paris Diderot, Hôpital Lariboisière - Centre Viggo Petersen)

  • Annelise Bennaceur-Griscelli

    (Université Paris Sud
    Université Paris Sud, Université Paris Saclay, UFR de Médecine Kremlin Bicêtre
    Service d’hématologie, APHP, GHU Paris Sud)

  • Hervé Acloque

    (Université Paris Sud
    Université Paris-Saclay)

Abstract

Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.

Suggested Citation

  • Eva Hadadi & William Taylor & Xiao-Mei Li & Yetki Aslan & Marthe Villote & Julie Rivière & Gaelle Duvallet & Charlotte Auriau & Sandrine Dulong & Isabelle Raymond-Letron & Sylvain Provot & Annelise Be, 2020. "Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16890-6
    DOI: 10.1038/s41467-020-16890-6
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