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Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Author

Listed:
  • Andrea Strakova

    (University of Cambridge)

  • Thomas J. Nicholls

    (University of Gothenburg
    Newcastle University)

  • Adrian Baez-Ortega

    (University of Cambridge)

  • Máire Ní Leathlobhair

    (University of Cambridge)

  • Alexander T. Sampson

    (University of Cambridge)

  • Katherine Hughes

    (University of Cambridge)

  • Isobelle A. G. Bolton

    (University of Cambridge)

  • Kevin Gori

    (University of Cambridge)

  • Jinhong Wang

    (University of Cambridge)

  • Ilona Airikkala-Otter

    (Worldwide Veterinary Service, International Training Center)

  • Janice L. Allen

    (Animal Management in Rural and Remote Indigenous Communities (AMRRIC))

  • Karen M. Allum

    (World Vets)

  • Clara L. Arnold

    (Hopkins Belize Humane Society)

  • Leontine Bansse-Issa

    (Animal Shelter, Stichting Dierenbescherming Suriname)

  • Thinlay N. Bhutia

    (Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim)

  • Jocelyn L. Bisson

    (University of Cambridge)

  • Kelli Blank

    (Hopkins Belize Humane Society)

  • Cristóbal Briceño

    (University of Chile)

  • Artemio Castillo Domracheva

    (University of Panamá)

  • Anne M. Corrigan

    (St. George’s University)

  • Hugh R. Cran

    (The Nakuru District Veterinary Scheme Ltd)

  • Jane T. Crawford

    (Animal Medical Centre)

  • Stephen M. Cutter

    (Animal Management in Rural and Remote Indigenous Communities (AMRRIC))

  • Eric Davis

    (UC Davis School of Veterinary Medicine)

  • Karina F. de Castro

    (Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto)

  • Andrigo B. De Nardi

    (São Paulo State University (UNESP))

  • Anna P. de Vos

    (Ladybrand Animal Clinic)

  • Laura Delgadillo Keenan

    (Veterinary Clinic Sr. Dog’s)

  • Edward M. Donelan

    (Animal Management in Rural and Remote Indigenous Communities (AMRRIC))

  • Adela R. Espinoza Huerta

    (World Vets Latin America Veterinary Training Center)

  • Ibikunle A. Faramade

    (National Veterinary Research Institute)

  • Mohammed Fazil

    (Animal Clinic)

  • Eleni Fotopoulou

    (Intermunicipal Stray Animals Care Centre (DIKEPAZ))

  • Skye N. Fruean

    (Animal Protection Society of Samoa)

  • Fanny Gallardo-Arrieta

    (University of Zulia)

  • Olga Glebova

    (Veterinary Clinic BIOCONTROL)

  • Pagona G. Gouletsou

    (University of Thessaly)

  • Rodrigo F. Häfelin Manrique

    (University of Chile)

  • Joaquim J. G. P. Henriques

    (OnevetGroup, Hospital Veterinário Berna)

  • Rodrigo S. Horta

    (Universidade Vila Velha)

  • Natalia Ignatenko

    (Veterinary Clinic Zoovetservis)

  • Yaghouba Kane

    (École Inter-états des Sciences et Médecine Vétérinaires de Dakar)

  • Cathy King

    (World Vets)

  • Debbie Koenig

    (World Vets)

  • Ada Krupa

    (Utrecht University)

  • Steven J. Kruzeniski

    (World Vets Latin America Veterinary Training Center)

  • Marta Lanza-Perea

    (St. George’s University)

  • Mihran Lazyan

    (Vetexpert Veterinary Group)

  • Adriana M. Lopez Quintana

    (Lopez Quintana Veterinary Clinic)

  • Thibault Losfelt

    (Clinique Veterinaire de Grand Fond, Saint Gilles les Bains)

  • Gabriele Marino

    (University of Messina)

  • Simón Martínez Castañeda

    (Universidad Autónoma del Estado de México)

  • Mayra F. Martínez-López

    (Universidad de las Américas)

  • Bedan M. Masuruli

    (Veterinary Council of Tanzania)

  • Michael Meyer

    (Touray & Meyer Vet Clinic)

  • Edward J. Migneco

    (Hillside Animal Hospital)

  • Berna Nakanwagi

    (The Kampala Veterinary Surgery)

  • Karter B. Neal

    (Asavet Veterinary Charities)

  • Winifred Neunzig

    (World Vets)

  • Sally J. Nixon

    (Vets Beyond Borders)

  • Antonio Ortega-Pacheco

    (Autonomous University of Yucatan)

  • Francisco Pedraza-Ordoñez

    (Universidad de Caldas)

  • Maria C. Peleteiro

    (University of Lisbon)

  • Katherine Polak

    (Four Paws International)

  • Ruth J. Pye

    (Vets Beyond Borders)

  • Juan C. Ramirez-Ante

    (Universidad de Caldas)

  • John F. Reece

    (Help in Suffering)

  • Jose Rojas Gutierrez

    (Veterinary Clinic Dr José Rojas)

  • Haleema Sadia

    (Balochistan University of Information Technology, Engineering and Management Sciences)

  • Sheila K. Schmeling

    (Corozal Veterinary Clinic)

  • Olga Shamanova

    (Veterinary Clinic Vetmaster)

  • Alan G. Sherlock

    (Vets Beyond Borders)

  • Audrey E. Steenland-Smit

    (Animal Shelter, Stichting Dierenbescherming Suriname)

  • Alla Svitich

    (State Hospital of Veterinary Medicine)

  • Lester J. Tapia Martínez

    (World Vets Latin America Veterinary Training Center)

  • Ismail Thoya Ngoka

    (Jomo Kenyatta University of Agriculture and Technology)

  • Cristian G. Torres

    (University of Chile)

  • Elizabeth M. Tudor

    (University of Melbourne)

  • Mirjam G. van der Wel

    (Animal Anti Cruelty League)

  • Bogdan A. Vițălaru

    (Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest)

  • Sevil A. Vural

    (Ankara University)

  • Oliver Walkinton

    (Vets Beyond Borders)

  • Alvaro S. Wehrle-Martinez

    (National University of Asuncion)

  • Sophie A. E. Widdowson

    (Lilongwe Society for Protection and Care of Animals (LSPCA))

  • Irina Zvarich

    (Veterinary clinic Canine Heart)

  • Patrick F. Chinnery

    (University of Cambridge)

  • Maria Falkenberg

    (University of Gothenburg)

  • Claes M. Gustafsson

    (University of Gothenburg)

  • Elizabeth P. Murchison

    (University of Cambridge)

Abstract

Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.

Suggested Citation

  • Andrea Strakova & Thomas J. Nicholls & Adrian Baez-Ortega & Máire Ní Leathlobhair & Alexander T. Sampson & Katherine Hughes & Isobelle A. G. Bolton & Kevin Gori & Jinhong Wang & Ilona Airikkala-Otter , 2020. "Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16765-w
    DOI: 10.1038/s41467-020-16765-w
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    Cited by:

    1. Khalid AbdulJabbar & Simon P. Castillo & Katherine Hughes & Hannah Davidson & Amy M. Boddy & Lisa M. Abegglen & Lucia Minoli & Selina Iussich & Elizabeth P. Murchison & Trevor A. Graham & Simon Spiro , 2023. "Bridging clinic and wildlife care with AI-powered pan-species computational pathology," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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