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A human monoclonal antibody blocking SARS-CoV-2 infection

Author

Listed:
  • Chunyan Wang

    (Utrecht University)

  • Wentao Li

    (Utrecht University)

  • Dubravka Drabek

    (Erasmus Medical Center
    Harbour BioMed)

  • Nisreen M. A. Okba

    (Erasmus Medical Center)

  • Rien Haperen

    (Erasmus Medical Center
    Harbour BioMed)

  • Albert D. M. E. Osterhaus

    (University of Veterinary Medicine)

  • Frank J. M. Kuppeveld

    (Utrecht University)

  • Bart L. Haagmans

    (Erasmus Medical Center)

  • Frank Grosveld

    (Erasmus Medical Center
    Harbour BioMed)

  • Berend-Jan Bosch

    (Utrecht University)

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

Suggested Citation

  • Chunyan Wang & Wentao Li & Dubravka Drabek & Nisreen M. A. Okba & Rien Haperen & Albert D. M. E. Osterhaus & Frank J. M. Kuppeveld & Bart L. Haagmans & Frank Grosveld & Berend-Jan Bosch, 2020. "A human monoclonal antibody blocking SARS-CoV-2 infection," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16256-y
    DOI: 10.1038/s41467-020-16256-y
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    Cited by:

    1. Niels Joachim Gormsen & Ralph S J Koijen & Nikolai Roussanov, 0. "Coronavirus: Impact on Stock Prices and Growth Expectations," The Review of Asset Pricing Studies, Society for Financial Studies, vol. 10(4), pages 574-597.
    2. Yifan Wang & Caixuan Liu & Chao Zhang & Yanxing Wang & Qin Hong & Shiqi Xu & Zuyang Li & Yong Yang & Zhong Huang & Yao Cong, 2022. "Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Safiyanu, Babangida Danladi & Isa, Musa & Lawan, Isah Isah, 2020. "Impact of COVID-19 on the Nigerian Stock Exchange Market," MPRA Paper 110408, University Library of Munich, Germany.
    4. Franziska K. Kaiser & Mariana Gonzalez Hernandez & Nadine Krüger & Ellinor Englund & Wenjuan Du & Anna Z. Mykytyn & Mathijs P. Raadsen & Mart M. Lamers & Francine Rodrigues Ianiski & Tatiana M. Shamor, 2024. "Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Chunyan Wang & Emma L. Hesketh & Tatiana M. Shamorkina & Wentao Li & Peter J. Franken & Dubravka Drabek & Rien Haperen & Sarah Townend & Frank J. M. Kuppeveld & Frank Grosveld & Neil A. Ranson & Joost, 2022. "Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. P. K. Mishra & S. K. Mishra, 2020. "Corona Pandemic and Stock Market Behaviour: Empirical Insights from Selected Asian Countries," Millennial Asia, , vol. 11(3), pages 341-365, December.
    7. Lei Peng & Yingxia Hu & Madeleine C. Mankowski & Ping Ren & Rita E. Chen & Jin Wei & Min Zhao & Tongqing Li & Therese Tripler & Lupeng Ye & Ryan D. Chow & Zhenhao Fang & Chunxiang Wu & Matthew B. Dong, 2022. "Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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