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Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues

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Listed:
  • Andrew R. Marderstein

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine
    Cornell University)

  • Manik Uppal

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Akanksha Verma

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Bhavneet Bhinder

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Zakieh Tayyebi

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Jason Mezey

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Cornell University)

  • Andrew G. Clark

    (Weill Cornell Medicine
    Cornell University)

  • Olivier Elemento

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

Abstract

Despite infiltrating immune cells having an essential function in human disease and patients’ responses to treatments, mechanisms influencing variability in infiltration patterns remain unclear. Here, using bulk RNA-seq data from 46 tissues in the Genotype-Tissue Expression project, we apply cell-type deconvolution algorithms to evaluate the immune landscape across the healthy human body. We discover that 49 of 189 infiltration-related phenotypes are associated with either age or sex (FDR

Suggested Citation

  • Andrew R. Marderstein & Manik Uppal & Akanksha Verma & Bhavneet Bhinder & Zakieh Tayyebi & Jason Mezey & Andrew G. Clark & Olivier Elemento, 2020. "Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16097-9
    DOI: 10.1038/s41467-020-16097-9
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