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Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

Author

Listed:
  • Noam Nitzan

    (Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center)

  • Sam McKenzie

    (Neuroscience Institute and Department of Neurology New York University Langone Medical Center)

  • Prateep Beed

    (Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center)

  • Daniel Fine English

    (Neuroscience Institute and Department of Neurology New York University Langone Medical Center
    School of Neuroscience, College of Science)

  • Silvia Oldani

    (Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center
    Center for Neurodegenerative Diseases (DZNE))

  • John J. Tukker

    (Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center
    Center for Neurodegenerative Diseases (DZNE))

  • György Buzsáki

    (Neuroscience Institute and Department of Neurology New York University Langone Medical Center
    Center for Neural Science, New York University)

  • Dietmar Schmitz

    (Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center
    Center for Neurodegenerative Diseases (DZNE)
    Cluster of Excellence NeuroCure
    Einstein Center for Neurosciences)

Abstract

Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.

Suggested Citation

  • Noam Nitzan & Sam McKenzie & Prateep Beed & Daniel Fine English & Silvia Oldani & John J. Tukker & György Buzsáki & Dietmar Schmitz, 2020. "Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15787-8
    DOI: 10.1038/s41467-020-15787-8
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