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Pre-clinical modeling of cutaneous melanoma

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Listed:
  • Vito W. Rebecca

    (Melanoma Research Center)

  • Rajasekharan Somasundaram

    (Melanoma Research Center)

  • Meenhard Herlyn

    (Melanoma Research Center)

Abstract

Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes melanoma as an ideal model for investigating therapy resistance. In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft. In particular, we highlight how each system recapitulates different features of melanoma adaptability and can be used to better understand melanoma development, progression and therapy resistance.

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  • Vito W. Rebecca & Rajasekharan Somasundaram & Meenhard Herlyn, 2020. "Pre-clinical modeling of cutaneous melanoma," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15546-9
    DOI: 10.1038/s41467-020-15546-9
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