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High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation

Author

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  • Wei He

    (School of Life Sciences and Medical School of Nanjing University
    Institute of Chinese Medical Sciences, University of Macau
    Anhui Medical University)

  • Jinzhi Xu

    (School of Life Sciences and Medical School of Nanjing University)

  • Ruoyu Mu

    (School of Life Sciences and Medical School of Nanjing University
    Institute of Chinese Medical Sciences, University of Macau)

  • Qiu Li

    (Institute of Chinese Medical Sciences, University of Macau)

  • Da-lun Lv

    (First Affiliated Hospital of Wannan Medical College, Jinghu District)

  • Zhen Huang

    (School of Life Sciences and Medical School of Nanjing University)

  • Junfeng Zhang

    (School of Life Sciences and Medical School of Nanjing University)

  • Chunming Wang

    (Institute of Chinese Medical Sciences, University of Macau)

  • Lei Dong

    (School of Life Sciences and Medical School of Nanjing University)

Abstract

High-salt diets are associated with an elevated risk of autoimmune diseases, and immune dysregulation plays a key role in cancer development. However, the correlation between high-salt diets (HSD) and cancer development remains unclear. Here, we report that HSD increases the local concentration of sodium chloride in tumour tissue, inducing high osmotic stress that decreases both the production of cytokines required for myeloid-derived suppressor cells (MDSCs) expansion and MDSCs accumulation in the blood, spleen, and tumour. Consequently, the two major types of MDSCs change their phenotypes: monocytic-MDSCs differentiate into antitumour macrophages, and granulocytic-MDSCs adopt pro-inflammatory functions, thereby reactivating the antitumour actions of T cells. In addition, the expression of p38 mitogen-activated protein kinase-dependent nuclear factor of activated T cells 5 is enhanced in HSD-induced M-MDSC differentiation. Collectively, our study indicates that high-salt intake inhibits tumour growth in mice by activating antitumour immune surveillance through modulating the activities of MDSCs.

Suggested Citation

  • Wei He & Jinzhi Xu & Ruoyu Mu & Qiu Li & Da-lun Lv & Zhen Huang & Junfeng Zhang & Chunming Wang & Lei Dong, 2020. "High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15524-1
    DOI: 10.1038/s41467-020-15524-1
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