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Graphene-based sensing of oxygen transport through pulmonary membranes

Author

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  • Mijung Kim

    (University of Illinois at Urbana-Champaign)

  • Marilyn Porras-Gomez

    (University of Illinois at Urbana-Champaign)

  • Cecilia Leal

    (University of Illinois at Urbana-Champaign)

Abstract

Lipid-protein complexes are the basis of pulmonary surfactants covering the respiratory surface and mediating gas exchange in lungs. Cardiolipin is a mitochondrial lipid overexpressed in mammalian lungs infected by bacterial pneumonia. In addition, increased oxygen supply (hyperoxia) is a pathological factor also critical in bacterial pneumonia. In this paper we fabricate a micrometer-size graphene-based sensor to measure oxygen permeation through pulmonary membranes. Combining oxygen sensing, X-ray scattering, and Atomic Force Microscopy, we show that mammalian pulmonary membranes suffer a structural transformation induced by cardiolipin. We observe that cardiolipin promotes the formation of periodic protein–free inter–membrane contacts with rhombohedral symmetry. Membrane contacts, or stalks, promote a significant increase in oxygen gas permeation which may bear significance for alveoli gas exchange imbalance in pneumonia.

Suggested Citation

  • Mijung Kim & Marilyn Porras-Gomez & Cecilia Leal, 2020. "Graphene-based sensing of oxygen transport through pulmonary membranes," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14825-9
    DOI: 10.1038/s41467-020-14825-9
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