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Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

Author

Listed:
  • Qi Han

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Josue D. Ordaz

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Nai-Kui Liu

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Zoe Richardson

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Wei Wu

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Yongzhi Xia

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Wenrui Qu

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Ying Wang

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Heqiao Dai

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Yi Ping Zhang

    (Norton Healthcare)

  • Christopher B. Shields

    (Norton Healthcare
    University of Louisville)

  • George M. Smith

    (Temple University)

  • Xiao-Ming Xu

    (Indiana University School of Medicine
    Indiana University School of Medicine)

Abstract

Locomotor function, mediated by lumbar neural circuitry, is modulated by descending spinal pathways. Spinal cord injury (SCI) interrupts descending projections and denervates lumbar motor neurons (MNs). We previously reported that retrogradely transported neurotrophin-3 (NT-3) to lumbar MNs attenuated SCI-induced lumbar MN dendritic atrophy and enabled functional recovery after a rostral thoracic contusion. Here we functionally dissected the role of descending neural pathways in response to NT-3-mediated recovery after a T9 contusive SCI in mice. We find that residual projections to lumbar MNs are required to produce leg movements after SCI. Next, we show that the spared descending propriospinal pathway, rather than other pathways (including the corticospinal, rubrospinal, serotonergic, and dopaminergic pathways), accounts for NT-3-enhanced recovery. Lastly, we show that NT-3 induced propriospino-MN circuit reorganization after the T9 contusion via promotion of dendritic regrowth rather than prevention of dendritic atrophy.

Suggested Citation

  • Qi Han & Josue D. Ordaz & Nai-Kui Liu & Zoe Richardson & Wei Wu & Yongzhi Xia & Wenrui Qu & Ying Wang & Heqiao Dai & Yi Ping Zhang & Christopher B. Shields & George M. Smith & Xiao-Ming Xu, 2019. "Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13854-3
    DOI: 10.1038/s41467-019-13854-3
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