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Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation

Author

Listed:
  • G. Torromino

    (Sapienza University of Rome)

  • L. Autore

    (Sapienza University of Rome)

  • V. Khalil

    (Sapienza University of Rome)

  • V. Mastrorilli

    (Sapienza University of Rome)

  • M. Griguoli

    (European Brain Research Institute (EBRI))

  • A. Pignataro

    (CNR - National Research Council, Institute of Translational Pharmacology
    IRCCS Santa Lucia Foundation)

  • E. Centofante

    (Sapienza University of Rome)

  • G. M. Biasini

    (Sapienza University of Rome)

  • V. De Turris

    (Istituto Italiano di Tecnologia (IIT))

  • M. Ammassari-Teule

    (IRCCS Santa Lucia Foundation)

  • A. Rinaldi

    (Sapienza University of Rome)

  • A. Mele

    (Sapienza University of Rome)

Abstract

The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum–ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.

Suggested Citation

  • G. Torromino & L. Autore & V. Khalil & V. Mastrorilli & M. Griguoli & A. Pignataro & E. Centofante & G. M. Biasini & V. De Turris & M. Ammassari-Teule & A. Rinaldi & A. Mele, 2019. "Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13703-3
    DOI: 10.1038/s41467-019-13703-3
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