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Genomic and immune profiling of pre-invasive lung adenocarcinoma

Author

Listed:
  • Haiquan Chen

    (Fudan University Shanghai Cancer Center
    Fudan University
    Fudan University
    Fudan University)

  • Jian Carrot-Zhang

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Yue Zhao

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Haichuan Hu

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Samuel S. Freeman

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Su Yu

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Gavin Ha

    (Fred Hutchinson Cancer Research Center)

  • Alison M. Taylor

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Ashton C. Berger

    (Broad Institute of MIT and Harvard)

  • Lindsay Westlake

    (Broad Institute of MIT and Harvard)

  • Yuanting Zheng

    (Fudan University
    Fudan University)

  • Jiyang Zhang

    (Fudan University
    Fudan University)

  • Aruna Ramachandran

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard)

  • Qiang Zheng

    (Fudan University
    Fudan University Shanghai Cancer Center)

  • Yunjian Pan

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Difan Zheng

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Shanbo Zheng

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Chao Cheng

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Muyu Kuang

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Xiaoyan Zhou

    (Fudan University
    Fudan University Shanghai Cancer Center)

  • Yang Zhang

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Hang Li

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Ting Ye

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Yuan Ma

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Zhendong Gao

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Xiaoting Tao

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Han Han

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Jun Shang

    (Fudan University
    Fudan University)

  • Ying Yu

    (Fudan University
    Fudan University)

  • Ding Bao

    (Fudan University
    Fudan University)

  • Yechao Huang

    (Fudan University
    Fudan University)

  • Xiangnan Li

    (Fudan University
    Fudan University)

  • Yawei Zhang

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Jiaqing Xiang

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Yihua Sun

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Yuan Li

    (Fudan University
    Fudan University Shanghai Cancer Center)

  • Andrew D. Cherniack

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard)

  • Joshua D. Campbell

    (Boston University)

  • Leming Shi

    (Fudan University
    Fudan University)

  • Matthew Meyerson

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard
    Harvard Medical School)

Abstract

Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment.

Suggested Citation

  • Haiquan Chen & Jian Carrot-Zhang & Yue Zhao & Haichuan Hu & Samuel S. Freeman & Su Yu & Gavin Ha & Alison M. Taylor & Ashton C. Berger & Lindsay Westlake & Yuanting Zheng & Jiyang Zhang & Aruna Ramach, 2019. "Genomic and immune profiling of pre-invasive lung adenocarcinoma," Nature Communications, Nature, vol. 10(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13460-3
    DOI: 10.1038/s41467-019-13460-3
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