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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Author

Listed:
  • Barbara Nicol

    (National Institute of Environmental Health Sciences)

  • Sara A. Grimm

    (National Institute of Environmental Health Sciences)

  • Frédéric Chalmel

    (Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085)

  • Estelle Lecluze

    (Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085)

  • Maëlle Pannetier

    (Université Paris Saclay)

  • Eric Pailhoux

    (Université Paris Saclay)

  • Elodie Dupin-De-Beyssat

    (INRA, UR1037 Fish Physiology and Genomics)

  • Yann Guiguen

    (INRA, UR1037 Fish Physiology and Genomics)

  • Blanche Capel

    (Duke University Medical Center)

  • Humphrey H.-C. Yao

    (National Institute of Environmental Health Sciences)

Abstract

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat, and human. In the mouse, RUNX1 marks the supporting cell lineage and becomes pre-granulosa cell-specific as the gonads differentiate. RUNX1 plays complementary/redundant roles with FOXL2 to maintain fetal granulosa cell identity and combined loss of RUNX1 and FOXL2 results in masculinization of fetal ovaries. At the chromatin level, RUNX1 occupancy overlaps partially with FOXL2 occupancy in the fetal ovary, suggesting that RUNX1 and FOXL2 target common sets of genes. These findings identify RUNX1, with an ovary-biased expression pattern conserved across species, as a regulator in securing the identity of ovarian-supporting cells and the ovary.

Suggested Citation

  • Barbara Nicol & Sara A. Grimm & Frédéric Chalmel & Estelle Lecluze & Maëlle Pannetier & Eric Pailhoux & Elodie Dupin-De-Beyssat & Yann Guiguen & Blanche Capel & Humphrey H.-C. Yao, 2019. "RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13060-1
    DOI: 10.1038/s41467-019-13060-1
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    Cited by:

    1. Moïra Rossitto & Stephanie Déjardin & Chris M. Rands & Stephanie Gras & Roberta Migale & Mahmoud-Reza Rafiee & Yasmine Neirijnck & Alain Pruvost & Anvi Laetitia Nguyen & Guillaume Bossis & Florence Ca, 2022. "TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Karina F. Rodriguez & Paula R. Brown & Ciro M. Amato & Barbara Nicol & Chia-Feng Liu & Xin Xu & Humphrey Hung-Chang Yao, 2022. "Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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